Inhibition of the dopamine transporter promotes lysosome biogenesis and ameliorates Alzheimer's disease–like symptoms in mice,Alzheimer's & Dementia

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Inhibition of the dopamine transporter promotes lysosome biogenesis and ameliorates Alzheimer's disease–like symptoms in mice
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2022-09-21 , DOI: 10.1002/alz.12776
Limin Yin ₁ , Jianhui Zhou _{2,

3} , Tianyou Li ₁ , Xinghua Wang ₃ , Wenlong Xue ₁ , Jie Zhang ₁ , Lingxi Lin ₁ , Ning Wang ₁ , Xinyi Kang ₁ , Yu Zhou _{2,

3,

4} , Hong Liu _{2,

3,

4} , Yang Li ₁

Affiliation

Lysosomes are degradative organelles that maintain cellular homeostasis and protein quality control. Transcription factor EB (TFEB)–mediated lysosome biogenesis enhances lysosome-dependent degradation and alleviates neurodegenerative diseases, but the mechanisms underlying TFEB regulation and modification are still poorly understood.

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