Lysosomes are degradative organelles that maintain cellular homeostasis and protein quality control. Transcription factor EB (TFEB)–mediated lysosome biogenesis enhances lysosome-dependent degradation and alleviates neurodegenerative diseases, but the mechanisms underlying TFEB regulation and modification are still poorly understood.

中文翻译：

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抑制多巴胺转运蛋白可促进溶酶体生物合成并改善小鼠的阿尔茨海默病样症状

溶酶体是维持细胞稳态和蛋白质质量控​​制的降解性细胞器。转录因子 EB (TFEB) 介导的溶酶体生物合成增强了溶酶体依赖性降解并减轻了神经退行性疾病，但人们对 TFEB 调控和修饰的潜在机制仍知之甚少。