2-Arachidonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice,Alcoholism: Clinical & Experimental Research

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2-Arachidonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice
Alcoholism: Clinical & Experimental Research Pub Date : 2022-09-20 , DOI: 10.1111/acer.14949
Amanda Morgan ₁ , Danielle Adank ₂ , Keenan Johnson ₁ , Emily Butler ₃ , Sachin Patel ₁

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Alcohol use disorder (AUD) commonly occurs in patients with chronic pain, and a major barrier to achieving abstinence and preventing relapse is the emergence of hyperalgesia during alcohol withdrawal. Elucidating novel therapeutic approaches to target hyperalgesia associated with alcohol withdrawal could have important implications for treating AUD. Here, we examined the role of 2-arachidonoylglycerol (2-AG)-mediated endocannabinoid (eCB) signaling in the regulation of hyperalgesia associated with alcohol withdrawal in mice. We tested the hypothesis that pharmacological augmentation of 2-AG signaling could reduce hyperalgesia during withdrawal.

中文翻译：

2-花生四烯酰甘油介导的内源性大麻素信号传导调节与小鼠酒精戒断相关的机械超敏反应

酒精使用障碍（AUD）通常发生在患有慢性疼痛的患者中，实现戒酒和防止复发的主要障碍是戒酒期间出现痛觉过敏。阐明针对与酒精戒断相关的痛觉过敏的新治疗方法可能对治疗 AUD 具有重要意义。在这里，我们研究了 2-花生四烯酰甘油 (2-AG) 介导的内源性大麻素 (eCB) 信号在调节小鼠酒精戒断相关痛觉过敏中的作用。我们测试了这样的假设：药物增强 2-AG 信号传导可以减少戒断期间的痛觉过敏。

更新日期：2022-09-20

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