Picein 的抗氧化作用及其神经保护潜力：文献综述,Molecules

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Picein 的抗氧化作用及其神经保护潜力：文献综述
Molecules ( IF 4.2 ) Pub Date : 2022-09-21 , DOI: 10.3390/molecules27196189
Leila Elyasi ₁ , Jessica M Rosenholm ₂ , Fatemeh Jesmi ₃ , Mehrdad Jahanshahi ₁

Affiliation

神经退行性疾病 (NDD) 是老年人痴呆症的主要原因，目前尚无治愈方法，因为目前可用的治疗方法主要是缓解症状。尽管进行了治疗，大多数 NDD 仍会进展，并最终导致患者在患者和护理人员承受数年负担后死亡。因此，有必要研究解决疾病发病机制并能有效减缓或阻止疾病进展的药物，以期治愈患者并防止进一步的负担和死亡率。因此，最近的研究集中在具有神经再生或神经保护作用的疾病缓解疗法上。为此，有必要了解 NDD 的发病机制。已经表明，氧化应激在中枢神经系统的损伤和神经退行性疾病的进展中起重要作用。此外，已经提出线粒体功能障碍和未折叠蛋白的积累，包括 β-淀粉样蛋白 (Aβ)、tau 蛋白和 α-突触核蛋白。因此，细胞和分子研究已经研究了几种天然化合物（草药和营养剂）的神经保护和抗氧化特性的功效。建议用于治疗和/或预防 NDD 的最受欢迎的草药包括细胞和分子研究调查了几种天然化合物（草药和营养剂）的神经保护和抗氧化特性的功效。建议用于治疗和/或预防 NDD 的最受欢迎的草药包括细胞和分子研究调查了几种天然化合物（草药和营养剂）的神经保护和抗氧化特性的功效。建议用于治疗和/或预防 NDD 的最受欢迎的草药包括Withania somnifera (ashwagandha)、人参、姜黄素、白藜芦醇、Baccopa monnieri和银杏叶. 在一些草药中，例如人参，临床前和临床证据可支持其有效性；然而，在其他一些情况下，只有细胞和动物研究可用。根据关于草药化合物对 NDDs 有效性的文献很少，还有其他草药药物被忽视了。Picein 是仅在少数研究中调查过的草药之一。Picein 是几种草药的活性成分，因此可以从不同类型的草药中提取，这使得它更容易获得。细胞和植物研究表明它具有抗炎特性；然而，迄今为止，只有一项研究表明了它的神经保护特性。此外，一些细胞研究表明，picein 没有抗炎作用。所以，需要对现有文献进行审查，以总结关于 picein 的研究结果。迄今为止，似乎还没有综述研究解决过这个问题。因此，在本研究中，我们收集了关于皮松的抗氧化和潜在神经保护特性及其治疗 NDDs 可能有效性的可用信息。我们还总结了可以从中提取picein的植物，以指导研究人员进行未来的研究。

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The Antioxidative Effects of Picein and Its Neuroprotective Potential: A Review of the Literature

Neurodegenerative diseases (NDDs) are the main cause of dementia in the elderly, having no cure to date, as the currently available therapies focus on symptom remission. Most NDDs will progress despite treatment and eventually result in the death of the patient after several years of a burden on both the patient and the caregivers. Therefore, it is necessary to investigate agents that tackle the disease pathogenesis and can efficiently slow down or halt disease progression, with the hope of curing the patients and preventing further burden and mortality. Accordingly, recent research has focused on disease-modifying treatments with neuroregenerative or neuroprotective effects. For this purpose, it is necessary to understand the pathogenesis of NDDs. It has been shown that oxidative stress plays an important role in the damage to the central nervous system and the progression of neurodegenerative disorders. Furthermore, mitochondrial dysfunction and the accumulation of unfolded proteins, including beta-amyloid (Aβ), tau proteins, and α-synuclein, have been suggested. Accordingly, cellular and molecular studies have investigated the efficacy of several natural compounds (herbs and nutritional agents) for their neuroprotective and antioxidative properties. The most popular herbs suggested for the treatment and/or prevention of NDDs include Withania somnifera (ashwagandha), ginseng, curcumin, resveratrol, Baccopa monnieri, and Ginkgo biloba. In some herbs, such as ginseng, preclinical and clinical evidence are available for supporting its effectiveness; however, in some others, only cellular and animal studies are available. In line with the scant literature in terms of the effectiveness of herbal compounds on NDDs, there are also other herbal agents that have been disregarded. Picein is one of the herbal agents that has been investigated in only a few studies. Picein is the active ingredient of several herbs and can be thus extracted from different types of herbs, which makes it more available. It has shown to have anti-inflammatory properties in cellular and plant studies; however, to date, only one study has suggested its neuroprotective properties. Furthermore, some cellular studies have shown no anti-inflammatory effect of picein. Therefore, a review of the available literature is required to summarize the results of studies on picein. To date, no review study seems to have addressed this issue. Thus, in the present study, we gather the available information about the antioxidative and potential neuroprotective properties of picein and its possible effectiveness in treating NDDs. We also summarize the plants from which picein can be extracted in order to guide researchers for future investigations.

更新日期：2022-09-21

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