Formation of Fluorovinyl Spiro-[imidazole-indene] and α-Amino-β-naphthalenones via Rh(III)-Catalyzed Cascade C–H Functionalization,Organic Letters

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Formation of Fluorovinyl Spiro-[imidazole-indene] and α-Amino-β-naphthalenones via Rh(III)-Catalyzed Cascade C–H Functionalization
Organic Letters ( IF 4.9 ) Pub Date : 2022-09-21 , DOI: 10.1021/acs.orglett.2c02711
Yi Luo ₁ , Han-Yi Zhou ₁ , Yi-Chi Gang ₁ , Lin Dong ₁

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An efficacious method for building fluorovinyl spiro-[imidazole-indene] and α-amino-β-naphthalenone skeletons synchronously has been shown to consist of Rh(III)-catalyzed C–H functionalization between 2H-imidazoles and difluoromethylene alkynes. This protocol demonstrates a practical and straightforward route for installing fluorine elements in the envisioned position of heterocyclic compounds.

中文翻译：

Rh(III)催化级联C-H官能化形成氟乙烯基螺-[咪唑-茚]和α-氨基-β-萘酮

同步构建氟乙烯基螺-[咪唑-茚]和 α-氨基-β-萘酮骨架的有效方法已被证明是由 Rh(III) 催化的 2 H-咪唑和二氟亚甲基炔烃之间的 C-H 官能化组成。该协议展示了在杂环化合物的预期位置安装氟元素的实用且直接的途径。

更新日期：2022-09-21

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