Depression and anxiety in women with malignant ovarian germ cell (MOGCT) and sex cord stromal tumors (SCST): an analysis of the AGO-CORSETT database,Archives of Gynecology and Obstetrics

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Depression and anxiety in women with malignant ovarian germ cell (MOGCT) and sex cord stromal tumors (SCST): an analysis of the AGO-CORSETT database
Archives of Gynecology and Obstetrics ( IF 2.1 ) Pub Date : 2022-09-21 , DOI: 10.1007/s00404-022-06781-0
M Bossart _{1,

2} , H Plett ₃ , B Krämer ₄ , E Braicu ₅ , B Czogalla ₆ , M Klar ₁ , S Singer _{7,

8} , D Mayr ₉ , A Staebler ₁₀ , A du Bois ₃ , S Kommoss ₄ , T Link ₁₁ , A Burges ₆ , F Heitz ₃ , M Grube ₄ , F Trillsch ₆ , P Harter ₃ , P Wimberger ₁₁ , P Buderath ₁₂ , A Hasenburg ₈

Affiliation

Department of Gynecology and Obstetrics, University Medical Center Freiburg, Freiburg im Breisgau, Germany.
Department of Gynecology and Obstetrics, St. Josefskrankenhaus Freiburg, Freiburg im Breisgau, Germany.
Department of Gynecology & Gynecologic Oncology, Ev. Kliniken Essen-Mitte (KEM), Essen, Germany.
Department of Women's Health, Tuebingen University Hospital, Tuebingen, Germany.
Department of Gynecology, Charité Berlin, Campus Virchow Clinic, Berlin, Germany.
Department of Obstetrics and Gynecology, University Hospital, Ludwig- Maximilians- University Munich, Munich, Germany.
Institute of Medical Biostatistics, Epidemiology and Informatics, Division of Epidemiology and Health Care Research, University Medical Center Mainz, Mainz, Germany.
Department of Gynecology and Obstetrics, University Medical Center Mainz, Mainz, Germany.
Institut of Pathology, Ludwig-Maximilians- University Munich, Munich, Germany.
Division of Gynecologic Pathology, Institute of Pathology and Neuropathology, University of Tuebingen, Tuebingen, Germany.
Department of Gynecology and Obstetrics, Technische Universität Dresden Dresden and National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.
Department of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany.

Introduction

The intention of this study was to evaluate the level of anxiety and depression of malignant ovarian germ cell (MOGCT) and sex cord stromal tumors (SCST) survivors and to identify possible alterable cofactors.

Methods

CORSETT was an observational, multicenter, mixed retrospective/prospective cohort study of the AGO Studygroup. Women who had been diagnosed with MOGCTs and SCSTs between 2001 and 2011 were asked to complete the Hospital Anxiety and Depression Scale (HADS) to evaluate distress. Predictors of distress (type of surgery, chemotherapy, time since diagnosis, recurrence, second tumor, pain) were investigated using multivariate linear regression analysis.

Results

150 MOGCT and SCST patients with confirmed histological diagnosis completed the questionnaire median seven years after diagnosis. They had a HADS total score ≥ 13 indicating severe mental distress in 34% of cases. Patients after fertility-conserving surgery had lower probability of severe mental distress than those without fertility-conserving treatment (β = − 3.1, p = 0.04). Pain was associated with the level of distress in uni- and multivariate analysis (coef 0.1, p < 0.01, coef. Beta 0.5).

Discussion

Severe mental distress was frequent in patients with MOGCT and SCST and the level of pain was associated with the level of distress. Fertility conserving therapy, however, was associated with less mental distress. Screening and treatment of pain and depression is required to improve mental well-being in survivors of MOGCT and SCST.

中文翻译：

患有恶性卵巢生殖细胞 (MOGCT) 和性索间质瘤 (SCST) 的女性的抑郁和焦虑：AGO-CORSETT 数据库的分析

介绍

本研究的目的是评估恶性卵巢生殖细胞 (MOGCT) 和性索间质瘤 (SCST) 幸存者的焦虑和抑郁水平，并确定可能的可变辅助因子。

方法

CORSETT 是 AGO 研究组的一项观察性、多中心、混合的回顾性/前瞻性队列研究。要求在 2001 年至 2011 年间被诊断患有 MOGCT 和 SCST 的女性完成医院焦虑和抑郁量表 (HADS) 以评估痛苦。使用多变量线性回归分析研究了痛苦的预测因素（手术类型、化疗、自诊断以来的时间、复发、第二肿瘤、疼痛）。

结果

150 名经证实组织学诊断的 MOGCT 和 SCST 患者在诊断后平均 7 年完成问卷调查。他们的 HADS 总分 ≥ 13，表明 34% 的病例存在严重的精神痛苦。与未接受生育保护治疗的患者相比，接受生育保护手术的患者出现严重精神痛苦的可能性较低 ( β = − 3.1, p = 0.04)。在单变量和多变量分析中，疼痛与痛苦程度相关（系数 0.1，p < 0.01，系数 Beta 0.5）。