Fe2O3@SiO2@Eu-MOF@Tb-MOF 核/多壳纳米粒子用于阿司匹林和急性心肌梗死生物标志物的荧光传感,ACS Applied Nano Materials

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Fe2O3@SiO2@Eu-MOF@Tb-MOF 核/多壳纳米粒子用于阿司匹林和急性心肌梗死生物标志物的荧光传感
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2022-09-20 , DOI: 10.1021/acsanm.2c03688
Yang Fan Shi ₁ , Yu Peng Jiang ₁ , Xing Ze Wang ₁ , Zi Qing Zhang ₁ , Jian Zhong Huo ₁ , Yuan Yuan Liu ₁ , Xin Rui Wang ₁ , Bin Ding ₁

Affiliation

作为一种危险的心血管疾病，急性心肌梗死（AMI）夺走了无数患者的生命。AMI 的症状发作伴随着大量的 AMI 生物标志物，包括肌酸激酶同工酶 (CK-MB)、肌钙蛋白 I (CTn I) 和肌红蛋白 (Mb)。另一方面，阿司匹林是治疗AMI的有效药物。在此，我们应用逐层（LBL）合成策略形成分层磁芯/多壳镧系金属有机骨架（Ln-MOF）Fe ₂ O ₃ @SiO ₂ @Eu-MOF@Tb-MOF（MagMOF）纳米球。此外，靶 mRNA 序列和抗体（NH ₂AMI 生物标志物的-mRNA、抗 CTn 和抗 Mb) 分别与 MagMOF 组合。它们可用作混合传感平台，以高灵敏度检测 CK-MB、Mb 和 CTn I（CK-MB 的检测限 (LOD) 为 174.98 UL ^–1，CTn I 为 0.16 mg L ^–1，Mb 为 0.94 mg L ^–1 )。MagMOF对人血清中CK-MB、Mb和CTn I的检测范围已分别覆盖了它们在人体内的最大正常范围。此外，将 MagMOF 应用于阿司匹林的比率检测，具有高灵敏度和低限检测 (LOD = 0.43 μM)。因此，MagMOF 是第一个实现对这些 AMI 生物标志物的稳定、敏感、快速和方便的检测和治疗药物阿司匹林的例子。

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Fe2O3@SiO2@Eu-MOF@Tb-MOF Core/Multishell Nanoparticles for the Fluorescence Sensing of Aspirin and Acute Myocardial Infarction Biomarkers

As a dangerous cardiovascular disease, acute myocardial infarction (AMI) has taken the lives of countless patients. Symptom onset of AMI is accompanied by a high amount of AMI biomarkers, including creatine kinase isoenzyme (CK-MB), troponin I (CTn I), and myoglobin (Mb). On the other hand, aspirin is an effective curing drug for AMI. Herein, we applied the layer-by-layer (LBL) synthesis strategy to form stratified magnetic core/multishell lanthanide metal–organic framework (Ln-MOF) Fe₂O₃@SiO₂@Eu-MOF@Tb-MOF (MagMOF) nanoballs. Further, target mRNA sequence and antibodies (NH₂-mRNA, anti-CTn, and anti-Mb) for AMI biomarkers are combined with MagMOF, respectively. They can be utilized as a hybrid sensing platform for the detection of CK-MB, Mb, and CTn I with high sensitivity (the limit of detection (LOD) for CK-MB is 174.98 U L^–1, for CTn I is 0.16 mg L^–1, and for Mb is 0.94 mg L^–1). The detection ranges of MagMOF toward CK-MB, Mb, and CTn I in human serum have covered their maximum normal range in the human body, respectively. Further, MagMOF was applied in the ratiometric detection of aspirin with high sensitivity and low limit detection (LOD = 0.43 μM). As a result, MagMOF is the first example of realizing stable, susceptible, fast, and convenient detection of these AMI biomarkers and curing drug aspirin.

更新日期：2022-09-20

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