Quantifying Reductive Amination in Nonenzymatic Amino Acid Synthesis,Angewandte Chemie International Edition

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Quantifying Reductive Amination in Nonenzymatic Amino Acid Synthesis
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-09-19 , DOI: 10.1002/anie.202212237
Robert J Mayer ₁ , Joseph Moran _{1,

2}

Affiliation

Why does biochemical amino acid synthesis proceed the way it does? Kinetic and mechanistic experiments with a model hydride donor were used to determine the intrinsic electrophilic reactivities of keto acids in reduction and reductive amination reactions. Comparing the nonenzymatic reactivity trends with those found in biology provides new insight into the structure of amino acid metabolism.

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