基于单原子锰纳米酶的肿瘤响应与NIR-II光子热协同催化治疗,Advanced Functional Materials

当前位置： X-MOL 学术 › Adv. Funct. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

基于单原子锰纳米酶的肿瘤响应与NIR-II光子热协同催化治疗
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2022-09-18 , DOI: 10.1002/adfm.202206157
Jin Ye ₁ , Wubin Lv ₁ , Chunsheng Li ₁ , Shuang Liu _{1,

2} , Xing Yang ₁ , Jiangwei Zhang ₂ , Chen Wang ₃ , Jiating Xu _{1,

4} , Guanqiao Jin ₃ , Bin Li ₁ , Yujie Fu ₅ , Xinqiang Liang ₃

Affiliation

单原子纳米酶（SAzymes）由于其原子分散的活性位点，可以在原子水平上有效地模拟天然酶的金属活性中心，从而最大限度地提高原子利用效率和活性位点密度。因此，SAzymes 可被认为是最有希望替代天然酶的候选者。在此，设计了一种采用配位辅助聚合热解策略的聚乙二醇化介孔锰基单原子纳米酶 (PmMn/SAE)，该策略使用聚多巴胺进行光热增强纳米催化治疗。由于原子级分散的锰活性物质，PmMn/SAE 表现出优异的多种酶促性能，包括类过氧化氢酶、类氧化酶和类过氧化物酶 (POD) 性能。因此，PmMn/SAE 不仅催化内源性 H _2的分解O ₂产生O ₂以缓解肿瘤内部的缺氧，同时也将电子转移到O ₂产生超氧自由基以杀死肿瘤细胞。同时，PmMn/SAE能够触发类芬顿反应产生剧毒的羟基自由基，从而诱导癌细胞凋亡。利用实验结果和密度泛函理论揭示了 mMn/SAE 的类 POD 催化机制。此外，PmMn/SAE 在第二个近红外区域 (1064 nm) 显示出良好的光热转换效率 (η = 22.1%)。体外和体内实验结果均表明 PmMn/SAE 可通过光热增强催化疗法有效杀伤癌细胞。

"点击查看英文标题和摘要"

Tumor Response and NIR-II Photonic Thermal Co-Enhanced Catalytic Therapy Based on Single-Atom Manganese Nanozyme

Single-atom nanozymes (SAzymes) can effectively mimic the metal active centers of natural enzymes at the atomic level owing to their atomically dispersed active sites, thereby maximizing atom utilization efficiency and density of active sites. Hence, SAzymes can be considered the most promising candidates to replace natural enzymes. Herein, a PEGylated mesoporous Mn-based single-atom nanozyme (PmMn/SAE) employing a coordination-assisted polymerization pyrolysis strategy that uses polydopamine for photothermal-augmented nanocatalytic therapy is designed. PmMn/SAE exhibits excellent multiple enzymatic performance, including catalase-like, oxidase-like, and peroxidase (POD)-like performance, due to the atomically dispersed Mn active species. As a result, PmMn/SAE not only catalyzes the decomposition of endogenous H₂O₂ to generate O₂ for relieving hypoxia inside the tumor but also transfers electrons to O₂ to produce superoxide radicals to kill tumor cells. Meanwhile, PmMn/SAE is able to trigger Fenton-like reactions to generate highly toxic hydroxyl radicals to induce cancer cell apoptosis. The POD-like catalytic mechanism of mMn/SAE is revealed using experimental results and density functional theory. Furthermor, PmMn/SAE shows good photothermal conversion efficiency (η = 22.1%) in the second near-infrared region (1064 nm). Both the in vitro and in vivo experimental results indicate that PmMn/SAE can effectively kill cancer cells through photothermal-enhanced catalytic therapy.

更新日期：2022-09-18

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南