Bioresponsive Controlled Release Using Mesoporous Silica Nanoparticles Capped with Aptamer-Based Molecular Gate,Journal of the American Chemical Society

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Bioresponsive Controlled Release Using Mesoporous Silica Nanoparticles Capped with Aptamer-Based Molecular Gate
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2011-02-09 , DOI: 10.1021/ja110094g
Chun-Ling Zhu ₁ , Chun-Hua Lu ₂ , Xue-Yuan Song ₁ , Huang-Hao Yang ₂ , Xiao-Ru Wang ₁

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This communication describes the design of a novel and general bioresponsive controlled-release mesoporous silica (MS) nanoparticles system based on aptamer-target interactions. In this system, the pores of MS were capped with Au nanoparticles modified with aptamer (ATP aptamer in this case). By a competitive displacement reaction, the Au nanoparticles were uncapped in the presence of ATP molecule, and the cargo was released. Our results demonstrated that the aptamer-target interaction may be a promising route for the design of custom-made controlled-release nanodevices specifically governed by target biomolecules. Since aptamers have been obtained for a broad range of targets, including several cancer biomarkers, we believe that this aptamer-based controlled-release system should have an equally broad spectrum of applications.

中文翻译：

使用基于适体分子门的介孔二氧化硅纳米颗粒进行生物响应控制释放

该通讯描述了一种基于适体-靶标相互作用的新型通用生物响应控制释放介孔二氧化硅 (MS) 纳米粒子系统的设计。在该系统中，MS 的孔被适配体（在这种情况下为 ATP 适配体）修饰的 Au 纳米粒子覆盖。通过竞争性置换反应，Au 纳米颗粒在 ATP 分子的存在下被解开，并释放货物。我们的结果表明，适体-靶标相互作用可能是设计专门由靶标生物分子控制的定制控释纳米器件的有希望的途径。由于已经获得了广泛靶标的适体，包括几种癌症生物标志物，我们相信这种基于适体的控释系统应该具有同样广泛的应用范围。

更新日期：2011-02-09

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