Metal-organic framework (MOF) derivatives with unique physicochemical and electronic properties have seen a tremendous growth in diverse applications. Organic optobioelectronics have long been pursued in modern electronics for next-generation bio-relevant implementations. The intersection of these two disciplines could be an appealing way to pursue better performance of materials and devices. Herein this work reports the exploration of MOF derivatives and its ionic modulation for gating organic photoelectrochemical transistor (OPECT) biosensing. In the representative system of poly(ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) gated by zeolitic-imidazolate-framework (ZIF)-8-derived Cd_xZn_1-xS, a high current gain could be achieved at zero gate bias. In connection to a CuO nanoparticle-labeled sandwich immunoassay, acidolysis-triggered Cu²⁺-induced ionic modulation of the system results into a good performance toward human IgG with a low limit of detection of 0.003 pg/mL. This work features the MOF derivative-gated organic electronics and is expected to inspire more interest to explore various MOF derivative electronics with unknown possibilities, considering the diversity of MOF derivatives.

具有独特物理化学和电子特性的金属有机框架 (MOF) 衍生物在各种应用中取得了巨大的增长。有机光生物电子学长期以来一直在现代电子学中用于下一代生物相关实施。这两个学科的交叉可能是追求更好的材料和设备性能的一种有吸引力的方式。在此，这项工作报告了 MOF 衍生物及其用于门控有机光电化学晶体管 (OPECT) 生物传感的离子调制的探索。在聚（乙撑二氧噻吩）的代表性体系中：聚（苯乙烯磺酸盐）（PEDOT：PSS）由沸石-咪唑骨架（ZIF）-8衍生的Cd _x Zn _1-x门控S，可以在零栅极偏置下实现高电流增益。对于 CuO 纳米颗粒标记的夹心免疫测定，酸解触发的 Cu ²⁺诱导的系统离子调节导致对人 IgG 的良好性能，检测下限为 0.003 pg/mL。考虑到 MOF 衍生物的多样性，这项工作以 MOF 衍生物门控有机电子学为特色，并有望激发更多的兴趣来探索具有未知可能性的各种 MOF 衍生物电子学。