携带氧化镁纳米颗粒的生物合成绷带通过调节内源性骨膜细胞诱导皮质骨形成,ACS Nano

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携带氧化镁纳米颗粒的生物合成绷带通过调节内源性骨膜细胞诱导皮质骨形成
ACS Nano ( IF 15.8 ) Pub Date : 2022-09-15 , DOI: 10.1021/acsnano.2c04747
Xu Li _{1,

2} , Bingyang Dai _{1,

2} , Jiaxin Guo _{1,

2} , Yuwei Zhu ₃ , Jiankun Xu _{1,

2} , Shunxiang Xu _{1,

2} , Zhi Yao _{1,

2} , Liang Chang _{1,

2} , Ye Li _{1,

2} , Xuan He _{1,

2} , Dick Ho Kiu Chow _{1,

2} , Shian Zhang _{1,

2} , Hao Yao _{1,

2} , Wenxue Tong _{1,

2} , To Ngai ₃ , Ling Qin _{1,

2}

Affiliation

经常进行骨移植以治疗因外伤和肿瘤切除引起的骨缺损，但具有重大的医疗和社会经济负担。占位骨替代物在控制骨整合方面仍然具有挑战性，同时通过使用非占位植入物激活内源性骨膜细胞以促进新骨形成成为另一种治疗策略。在这里，我们制造了一种基于镁的人造绷带，它具有用于激活骨膜相关生物矿化的最佳微图案。胶原蛋白在嵌入电纺纤维膜的氧化镁纳米粒子表面自组装为分层绷带结构，以促进原位与骨膜的整合。皮质骨表面植入后在体内，通过激活内源性骨膜巨噬细胞为M2表型，释放镁离子以产生促成骨免疫微环境，同时促进血管形成和神经突生长。在皮质骨缺损模型中，镁基人工绷带引导周围新形成的骨组织覆盖缺损区域。综上所述，我们的研究表明，通过将镁原位输送到骨膜可以实现刺激骨形成的策略，并且所提出的骨膜绷带可作为加速骨愈合的生物活性介质。

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Biosynthesized Bandages Carrying Magnesium Oxide Nanoparticles Induce Cortical Bone Formation by Modulating Endogenous Periosteal Cells

Bone grafting is frequently conducted to treat bone defects caused by trauma and tumor removal, yet with significant medical and socioeconomic burdens. Space-occupying bone substitutes remain challenging in the control of osteointegration, and meanwhile activation of endogenous periosteal cells by using non-space-occupying implants to promote new bone formation becomes another therapeutic strategy. Here, we fabricated a magnesium-based artificial bandage with optimal micropatterns for activating periosteum-associated biomineralization. Collagen was self-assembled on the surface of magnesium oxide nanoparticles embedded electrospun fibrous membranes as a hierarchical bandage structure to facilitate the integration with periosteum in situ. After the implantation on the surface of cortical bone in vivo, magnesium ions were released to generate a pro-osteogenic immune microenvironment by activating the endogenous periosteal macrophages into M2 phenotype and, meanwhile, promote blood vessel formation and neurite outgrowth. In a cortical bone defect model, magnesium-based artificial bandage guided the surrounding newly formed bone tissue to cover the defected area. Taken together, our study suggests that the strategy of stimulating bone formation can be achieved with magnesium delivery to periosteum in situ and the proposed periosteal bandages act as a bioactive media for accelerating bone healing.

更新日期：2022-09-15

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