An unprecedent [4 + 3] cycloaddition of furoketenimines with furocarbenoids has been disclosed for the divergent and efficient synthesis of cycloheptafuran and cycloheptapyrrole scaffolds. Zinc chloride acted as promoters for both the formation of these two transient intermediates from isocyanides and ene‑yne-ketones, and the subsequent construction of seven-membered ring. Three rings and five bonds were constructed successively in this three-component one-pot domino reaction.

中文翻译：

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[4+3] 烯酮亚胺与呋喃类胡萝卜素的环加成：融合环庚三烯和托酮支架的发散和高效合成

已经公开了呋喃酮亚胺与呋喃类胡萝卜素的前所未有的 [4 + 3] 环加成，用于环庚呋喃和环庚吡咯支架的发散和有效合成。氯化锌作为异氰化物和烯炔酮这两种瞬时中间体的形成以及随后七元环的构建的促进剂。在这种三组分一锅多米诺骨牌反应中，三个环和五个键被依次构建。