Isoprenol (3-methyl-3-buten-1-ol) is produced industrially from aqueous formaldehyde and isobutene. In the process, mixtures of formaldehyde, water, and isoprenol are separated by distillation. As formaldehyde reacts with both water and isoprenol, these mixtures are reactive multicomponent systems. Information on the distillation behavior of these mixtures is lacking in the literature. We have therefore carried out single-stage batch distillation experiments to determine residue curves in the system (formaldehyde + water + isoprenol) at pressures between 5 and 80 kPa. Furthermore, we have used a physico-chemical vapor–liquid equilibrium model, in which the complex reactions in the studied system are explicitly considered, to calculate residue curve maps for the system (formaldehyde + water + isoprenol). They reveal a complex, strongly pressure-dependent topology with several azeotropes. The results from the batch distillation experiments confirm the predicted residue curves.

异戊二烯醇 (3-methyl-3-buten-1-ol) 在工业上由含水甲醛和异丁烯生产。在此过程中，甲醛、水和异戊二烯醇的混合物通过蒸馏分离。由于甲醛与水和异戊二烯醇都发生反应，因此这些混合物是反应性多组分系统。文献中缺乏关于这些混合物的蒸馏行为的信息。因此，我们进行了单级间歇蒸馏实验，以确定压力在 5 至 80 kPa 之间的系统中的残留曲线（甲醛 + 水 + 异戊二烯醇）。此外，我们使用了物理化学汽液平衡模型，其中明确考虑了所研究系统中的复杂反应，以计算系统的残留曲线图（甲醛 + 水 + 异戊二烯醇）。它们揭示了一个复杂的，具有多种共沸物的强压力依赖性拓扑。分批蒸馏实验的结果证实了预测的残渣曲线。