Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases. Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently open the BBB, providing a potential strategy for drug delivery across the BBB into the brain. Nowadays, taking advantage of this technology, many therapeutic agents, such as antibodies, growth factors, and nanomedicine formulations, are intensively investigated across the BBB into specific brain regions for the treatment of various brain diseases. Several preliminary clinical trials also have demonstrated its safety and good tolerance in patients. This review gives an overview of the basic mechanisms, ultrasound contrast agents, evaluation or monitoring methods, and medical applications of FUS-mediated BBB opening in glioblastoma, Alzheimer's disease, and Parkinson's disease.

血脑屏障 (BBB) 仍然是脑疾病药物治疗的重大障碍。聚焦超声 (FUS) 结合微泡 (MBs) 可以局部和瞬时打开 BBB，为药物通过 BBB 输送到大脑提供了潜在的策略。如今，利用这项技术，许多治疗剂，如抗体、生长因子和纳米药物制剂，都在 BBB 深入研究特定的大脑区域，以治疗各种脑部疾病。几项初步临床试验也证明了其在患者中的安全性和良好的耐受性。本综述概述了 FUS 介导的 BBB 在胶质母细胞瘤、阿尔茨海默病、