<br>肿瘤浸润性 CD226+CD8+ T 细胞与胃癌患者的术后预后和辅助化疗益处相关,Journal of Cancer Research and Clinical Oncology

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肿瘤浸润性 CD226+CD8+ T 细胞与胃癌患者的术后预后和辅助化疗益处相关
Journal of Cancer Research and Clinical Oncology ( IF 2.7 ) Pub Date : 2022-09-15 , DOI: 10.1007/s00432-022-04346-x
Yu Zhang _{1,

2} , Zhen-Xiong Zhao _{1,

2} , Jian-Peng Gao _{1,

2} , Ya-Kai Huang _{1,

2} , Hua Huang _{1,

2}

Affiliation

目的

定义胃癌（GC）中 CD8⁺T 细胞亚群的表型特征有助于重塑肿瘤的免疫微环境，从而改善患者的预后。CD226 最近已被证明在几种恶性肿瘤中调节 CD8⁺T 细胞的活性。然而，CD226 ⁺ CD8 ⁺ T 细胞在 GC 中的临床相关性仍不清楚。

方法

复旦大学上海肿瘤医院（FUSCC）队列（n = 316）、癌症基因组图谱（TCGA）队列（n = 407）、KUGH/KUCM 队列（n = 202）和亚洲癌症研究组（ACRG）队列（n = 300）被纳入预后和对辅助化疗（ACT）的反应分析。流式细胞术和多重免疫染色对 CD226⁺CD8⁺T 细胞进行表征。

结果

CD226⁺CD8⁺T 细胞预测 GC 根治性切除术患者预后良好。CD226 ⁺ CD8 ⁺ T 细胞浸润率高的 GC 患者从辅助化疗中获益更多。CD155 在 GC 组织中上调，与肿瘤内 CD226⁺CD8⁺T 细胞浸润减少有关。肿瘤内 CD226 ⁺ CD8 ⁺ T 细胞和 CD155 的组合是 GC 患者的强预后预测因子。

结论

CD226⁺CD8⁺T 细胞可能代表 GC 患者的新型治疗靶点和预后和治疗反应的有用标志物。

"点击查看英文标题和摘要"

Tumor-infiltrating CD226+CD8+ T cells are associated with postoperative prognosis and adjuvant chemotherapeutic benefits in gastric cancer patients

Purpose

Defining the phenotypic characteristics of CD8⁺ T cell subsets in gastric cancer (GC) can help remodel the immune microenvironment of the tumor, thereby improving patient prognosis. CD226 has recently been shown to regulate the activity of CD8⁺ T cell in several malignancies. However, the clinical relevance of CD226⁺CD8⁺ T cells in GC remains unclear.

Methods

Fudan University Shanghai Cancer Center (FUSCC) cohort (n = 316), The Cancer Genome Atlas (TCGA) cohort (n = 407), KUGH/KUCM cohort (n = 202), and Asian Cancer Research Group (ACRG) cohort (n = 300) were included in prognosis and response to adjuvant chemotherapy (ACT) analyses. Flow cytometry and multiplex immunostaining were used to characterize CD226⁺CD8⁺ T cells.

Results

CD226⁺CD8⁺ T cells predicted favorable outcomes in patients undergoing curative resection for GC. GC patients with high CD226⁺CD8⁺ T cell infiltration benefitted more from adjuvant chemotherapy. CD155 is upregulated in GC tissues and is associated with decreased intra-tumoral CD226⁺CD8⁺ T cell infiltration. The combination of intra-tumoral CD226⁺CD8⁺ T cells and CD155 is a strong prognostic predictor in patients with GC.