Oncogene ( IF 6.9 ) Pub Date : 2022-09-15 , DOI: 10.1038/s41388-022-02464-x
Yunfeng Gao 1 , Ming Jiang 1 , Fangqin Guo 1 , Xuejiao Liu 1, 2 , Qi Zhang 1 , Sen Yang 1 , Yiu To Yeung 3 , Ran Yang 1 , Keke Wang 1 , Qiong Wu 1, 2 , Dandan Zhang 1 , Chengjuan Zhang 4 , Kyle Vaughn Laster 1 , Mengmeng Ge 1 , Wenna Nie 1 , Kangdong Liu 1, 2, 5, 6 , Zigang Dong 1, 2, 5, 6
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Abnormal translation of the MYC proto-oncogene is a hallmark of the initiation and maintenance of tumorigenesis. However, the molecular mechanism underlying increased MYC protein levels in certain cancer types without a corresponding increase in MYC mRNA levels is unclear. Here, we identified a novel lncRNA, MTAR1, which is critical for post-transcriptional regulation of MYC-induced tumorigenesis. MTAR1 is essential for recruiting IGF2BPs into PABP1-mediated liquid–liquid phase separation (LLPS) complexes and facilitates IGF2BPs-mediated MYC mRNA translation. MTAR1 enhanced binding between IGF2BPs and PABP1, thereby promoting MYC mRNA stability and increased MYC mRNA translation. In summary, MTAR1 is a novel MYC-related lncRNA that contributes to tumor progression by enhancing MYC translation through mediating PABP1/IGF2BPs liquid–liquid phase separation.
中文翻译：
一种新型 lncRNA MTAR1 通过 IGF2BPs 介导的 c-MYC 转录后调控促进癌症发展
MYC 原癌基因的异常翻译是肿瘤发生启动和维持的标志。然而，某些癌症类型中 MYC 蛋白水平增加而 MYC mRNA 水平没有相应增加的分子机制尚不清楚。在这里，我们发现了一种新的 lncRNA，MTAR1，它对 MYC 诱导的肿瘤发生的转录后调控至关重要。MTAR1 对于将 IGF2BPs 募集到 PABP1 介导的液-液相分离 (LLPS) 复合物中至关重要，并促进 IGF2BPs 介导的 MYC mRNA 翻译。MTAR1 增强了 IGF2BPs 和 PABP1 之间的结合，从而促进了 MYC mRNA 的稳定性并增加了 MYC mRNA 的翻译。总之，
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