Underwater instant adhesion mechanism of self-assembled amphiphilic hemostatic granular hydrogel from Andrias davidianus skin secretion,iScience

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Underwater instant adhesion mechanism of self-assembled amphiphilic hemostatic granular hydrogel from Andrias davidianus skin secretion
iScience ( IF 4.6 ) Pub Date : 2022-09-09 , DOI: 10.1016/j.isci.2022.105106
Yuqing Liu ₁ , Yinghao Li _{2,

3} , Haitao Shang ₄ , Wen Zhong ₅ , Quan Wang ₆ , Kibret Mequanint _{7,

8} , Chuhong Zhu _{2,

9} , Malcolm Xing ₁ , Hong Wei ₄

Affiliation

Department of Mechanical Engineering, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Department of Anatomy, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Army Medical University (Third Military Medical University), Chongqing, 400038, China.
Chongqing Institute of Zhong Zhi Yi Gu, Shapingba District, Chongqing 400030, China.
Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.
Department of Biosystems Engineering, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Department of Civil Engineering, Shantou University, Shantou 515063, China.
Department of Chemical and Biochemical Engineering, University of Western Ontario, London, ON N6A 5B9, Canada.
School of Biomedical Engineering, University of Western Ontario, London, ON N6A 5B9, Canada.
State Key Laboratory of Trauma, Burn and Combined Injury, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Army Medical University (Third Military Medical University), Chongqing 400038, China.

The widespread use of biological tissue adhesives for tissue repair is limited by their weak adhesion in a wet environment. Herein, we report the wet adhesion mechanism of a dry granular natural bioadhesive from skin secretion (ADS). Once contacting water, ADS granules self-assemble to form a hydrophobic hydrogel strongly bonding to wet substrates in seconds. ADS showed higher shear adhesion than current commercial tissue adhesives and an impressive 72-h underwater adhesion strength of ∼47kPa on porcine skin tissue. The assembled hydrogel in water maintained a dissipation energy of ∼8 kJ/m, comparable to the work density of muscle, exhibiting its robustness. Unlike catechol adhesion mechanism, ADS wet adhesion mechanism is attributed to water absorption by granules, and the unique equilibrium of protein hydrophobicity, hydrogen bonding, and ionic complexation. The adhesion study demonstrated its excellent wet adhesion and hemostasis performance in a rat hepatic and cardiac hemorrhage model.

中文翻译：

大鲵皮肤分泌物自组装两亲性止血颗粒水凝胶水下瞬间粘附机制

生物组织粘合剂在组织修复中的广泛使用因其在潮湿环境中的粘合力较弱而受到限制。在此，我们报告了来自皮肤分泌物（ADS）的干燥颗粒天然生物粘合剂的湿粘附机制。一旦接触水，ADS 颗粒就会自组装形成疏水性水凝胶，在几秒钟内与湿基材牢固粘合。 ADS 显示出比目前商业组织粘合剂更高的剪切粘合力，并且在猪皮肤组织上的 72 小时水下粘合强度高达 47kPa，令人印象深刻。在水中组装的水凝胶保持~8 kJ/m的耗散能，与肌肉的工作密度相当，表现出其鲁棒性。与儿茶酚粘附机制不同，ADS湿粘附机制归因于颗粒的吸水性以及蛋白质疏水性、氢键和离子络合的独特平衡。粘附研究表明其在大鼠肝脏和心脏出血模型中具有优异的湿粘附和止血性能。

更新日期：2022-09-09

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