Background

Integrin subunit α -v (ITGAV) has been demonstrated to be dysregulated and involved in cancer promotion processes in a variety of cancers, but studies on nasopharyngeal carcinoma (NPC) have been limited. Our study aimed to comprehensively assess the expression level and potential mechanisms of ITGAV in NPC.

Results

A total of 13 mRNA expression datasets and internal tissue microarrays were included. ITGAV protein and mRNA were overexpressed in NPC. The pathways of upregulated genes positively related to ITGAV in NPC were analyzed, and the PI3K−Akt signaling pathway, cell cycle, and human papillomavirus infections were most significantly enriched. The protein–protein interaction network was constructed for the genes enriched in these pathways, and the corresponding hub genes were obtained. Among them, breast cancer susceptibility gene 1 (BRCA1) was predicted to be a transcription factor of ITGAV via the Cistrome DB Toolkit, which was also confirmed by ChIP-seq information and correlation calculations.

Conclusions

ITGAV is overexpressed in NPC and can regulate BRCA1 to participate in the cancer process. ITGAV serves as a potential therapeutic target in NPC patients.

How to cite: Huang S-W, Luo J-Y, Qin L-T, et al. Upregulation of ITGAV and the underlying mechanisms in nasopharyngeal carcinoma. Electron J Biotechnol 2022;60. https://doi.org/10.1016/j.ejbt.2022.09.002.

中文翻译：

---

ITGAV的上调及其在鼻咽癌中的潜在机制

背景

整合素亚基 α -v (ITGAV) 已被证明在多种癌症中失调并参与癌症促进过程，但对鼻咽癌 (NPC) 的研究受到限制。我们的研究旨在全面评估 ITGAV 在 NPC 中的表达水平和潜在机制。

结果

共包括 13 个 mRNA 表达数据集和内部组织微阵列。ITGAV 蛋白和 mRNA 在 NPC 中过表达。分析了鼻咽癌中与ITGAV正相关的上调基因的通路，其中PI3K-Akt信号通路、细胞周期和人乳头瘤病毒感染最显着富集。为这些途径中富集的基因构建蛋白质-蛋白质相互作用网络，得到相应的枢纽基因。其中，乳腺癌易感基因1（BRCA1）通过Cistrome DB Toolkit预测为ITGAV的转录因子，ChIP-seq信息和相关计算也证实了这一点。

结论

ITGAV 在 NPC 中过度表达，可以调节 BRCA1 参与癌症过程。ITGAV 可作为 NPC 患者的潜在治疗靶点。

引用方式： Huang SW, Luo JY, Qin LT, et al. ITGAV的上调及其在鼻咽癌中的潜在机制。电子 J 生物技术 2022；60。https://doi.org/10.1016/j.ejbt.2022.09.002。