Pr3+ 掺杂的 NaYF4 和 LiYF4 纳米晶体结合了可见光到 UVC 上转换和 NIR 到 NIR-II 下转换发光发射，用于生物医学应用,Nanoscale

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Pr3+ 掺杂的 NaYF4 和 LiYF4 纳米晶体结合了可见光到 UVC 上转换和 NIR 到 NIR-II 下转换发光发射，用于生物医学应用
Nanoscale ( IF 5.8 ) Pub Date : 2022-09-13 , DOI: 10.1039/d2nr01680j
Min Ying Tsang ₁ , Patryk Fałat ₁ , Magda A Antoniak ₁ , Roman Ziniuk ₂ , Szymon J Zelewski ₃ , Marek Samoć ₁ , Marcin Nyk ₁ , Junle Qu ₂ , Tymish Y Ohulchanskyy ₂ , Dominika Wawrzyńczyk ₁

Affiliation

镧系元素掺杂的氟化物纳米晶体 (NC) 具有独特的光学特性，例如上转换和下转换发光 (UCL 和 DCL)，可用于各种应用。在这项工作中，我们证明了通过将镨（III）和镱（III）离子（Pr ³⁺和 Yb ³⁺）掺杂到纳米氟化物基质（即NaYF ₄和 LiYF ₄）中，可以将它们的 UCL 和可同时用于生物医学应用的 DCL 属性。特别是，在与 Pr ³⁺和 Yb ^{3+共掺杂的单个纳米粒子中组合的发射模式}包括 DCL 发射（在 980 nm 处激发并在 1320 nm 处达到峰值），可用于生物组织透明度（~1000-1350 nm）的 NIR-II 窗口中的近红外 (NIR) DCL 生物成像和 UCL 发射（在447 nm，峰值在 275 nm），可用于杀菌作用（通过UVC 范围内的光照射）。双链 DNA (dsDNA) 变性为单链 DNA 证明了后者的可能性，这是由 NC 在 447 nm 照射下的 UVC UCL 发射引起的；在辐照的 dsDNA 溶液中观察到的高色素性以及 DNA 展开 (FADU) 测定的荧光分析证明了这一点。同时，证明了通过生物组织（牛齿和鸡肉）进行 NIR-II 发光生物成像的可能性。所提出的概念为使用镧系元素掺杂的氟化物纳米晶体的 NIR-II 成像引导的抗菌光疗法铺平了道路。

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Pr3+ doped NaYF4 and LiYF4 nanocrystals combining visible-to-UVC upconversion and NIR-to-NIR-II downconversion luminescence emissions for biomedical applications

Lanthanide-doped fluoride nanocrystals (NCs) are known to exhibit unique optical properties, such as upconversion and downconversion luminescence (UCL and DCL), which can be employed for various applications. In this work, we demonstrate that by doping praseodymium(III) and ytterbium(III) ions (Pr³⁺ and Yb³⁺) into a nanosized fluoride matrix (i.e. NaYF₄ and LiYF₄), it is possible to combine their UCL and DCL properties that can be concurrently used for biomedical applications. In particular, the emissive modes combined in a single nanoparticle co-doped with Pr³⁺ and Yb³⁺ include DCL emission (excited at 980 nm and peaked at 1320 nm), which can be used for near infrared (NIR) DCL bioimaging in the NIR-II window of biological tissue transparency (∼1000–1350 nm) and UCL emission (excited at 447 nm and peaked at 275 nm) that can be employed for germicide action (via irradiation by light in the UVC range). A possibility of the latter was demonstrated by the denaturation of double-stranded DNA (dsDNA) into single-stranded ones that was caused by the UVC UCL emission from the NCs under 447 nm irradiation; it was evidenced by the hyperchromicity observed in the irradiated dsDNA solution and also by a fluorometric analysis of DNA unwinding (FADU) assay. Concurrently, the possibility of NIR-II luminescence bioimaging through biological tissues (bovine tooth and chicken flesh) was demonstrated. The proposed concept paves a way for NIR-II imaging guided antimicrobial phototherapy using lanthanide-doped fluoride nanocrystals.

更新日期：2022-09-13

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