聚（1,8-辛二醇-柠檬酸共聚物）弹性体的整体侵蚀降解机制：体内和体外研究,Biomacromolecules

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聚（1,8-辛二醇-柠檬酸共聚物）弹性体的整体侵蚀降解机制：体内和体外研究
Biomacromolecules ( IF 5.5 ) Pub Date : 2022-09-12 , DOI: 10.1021/acs.biomac.2c00737
Lu Wan ₁ , Liangliang Lu ₂ , Tangsong Zhu ₁ , Zhichang Liu ₃ , Ruichun Du ₁ , Qiong Luo ₂ , Qiang Xu ₂ , Qiuhong Zhang ₁ , Xudong Jia _{1,

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Affiliation

作为一种可生物降解的弹性体，聚（1,8-辛二醇--柠檬酸盐) (POC) 已广泛应用于组织工程和植入电子学。然而，尚不明确的降解机制对POC的更好应用和发展提出了极大的挑战。为了揭示降解机制，在这里，我们对 POC 的体内和体外降解行为进行了系统研究。最初，研究了关键因素，包括化学结构、亲水和吸水特性以及 POC 的降解反应。然后，监测和讨论了 POC-x（具有不同交联密度的 POC）体外降解过程中各种降解引起的变化。结果表明：（1）交联密度随降解时间呈指数下降；(2) 质量损失和 PBS-吸收率呈非线性增长；(3) 截面上的形貌在微观水平上由平坦变为粗糙；(4) 立方体样品在宏观上不断膨胀直至坍塌成碎片；(5) 机械性能在降解开始时急剧下降。最后，研究了 POC-x 的体内降解行为，结果与体外相似。综合评估表明，POC 的体外和体内降解主要通过整体侵蚀发生。POC-x 降解引发的炎症反应与聚乳酸相当，甚至更不明显。此外，在这项工作中首次提出并进行了模拟应用环境中 POC 的机械评估，以获得更合适的应用。

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Bulk Erosion Degradation Mechanism for Poly(1,8-octanediol-co-citrate) Elastomer: An In Vivo and In Vitro Investigation

As a biodegradable elastomer, poly(1,8-octanediol-co-citrate) (POC) has been widely applied in tissue engineering and implantable electronics. However, the unclear degradation mechanism has posed a great challenge for the better application and development of POC. To reveal the degradation mechanism, here, we present a systematic investigation into in vivo and in vitro degradation behaviors of POC. Initially, critical factors, including chemical structures, hydrophilic and water-absorbency characteristics, and degradation reaction of POC, are investigated. Then, various degradation-induced changes during in vitro degradation of POC-x (POC with different cross-linking densities) are monitored and discussed. The results show that (1) cross-linking densities exponentially drop with degradation time; (2) mass loss and PBS-absorption ratio grow nonlinearly; (3) the morphology on the cross-section changes from flat to rough at a microscopic level; (4) the cubic samples keep swelling until they collapse into fragments from a macro view; and (5) the mechanical properties experience a sharp drop at the beginning of degradation. Finally, the in vivo degradation behaviors of POC-x are investigated, and the results are similar to those in vitro. The comprehensive assessment suggests that the in vitro and in vivo degradation of POC occurs primarily through bulk erosion. Inflammation responses triggered by the degradation of POC-x are comparable to poly(lactic acid), or even less obvious. In addition, the mechanical evaluation of POC in the simulated application environment is first proposed and conducted in this work for a more appropriate application. The degradation mechanism of POC revealed will greatly promote the further development and application of POC-based materials in the biomedical field.

更新日期：2022-09-12

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