Pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG) are two stages within the same ophthalmic disease spectrum, which are known to be affected by race. The prevalence of PDS is underestimated, largely due to its minor clinical symptoms. Although the prevalence of PG is low, the visual impairment associated with PG is extremely severe. The prevalence of PDS-PG is four or more times higher in Caucasians than in Blacks or Asians, and the “classic” PDS in Caucasians has long been used as a benchmark diagnostic criterion. Following extensive research focused on African Americans and Asians, the standard for diagnosing PDS-PG was refined. At the same time, the pathogenesis of PDS is not the same in different races. Hence, the effectiveness of preventive treatment and the need for treatment may not be equivalent in different races. The rate of conversion of PDS to PG is nearly 1/3 in Caucasians and higher in blacks and Asians, requiring more aggressive treatment and monitoring. We systematically searched a PubMed database from inception to March 2022 to provide an overview of research progress in various aspects of PDS-PG. Specifically, this paper considers the effects of race on disease prevalence, clinical manifestation, diagnostic criteria, disease mechanism, hereditary traits, treatment, and prevention to provide an accurate and comprehensive guide for the diagnosis and treatment of PDS-PG in various races.

色素弥散综合征 (PDS) 和色素性青光眼 (PG) 是同一眼科疾病谱中的两个阶段，已知它们受种族影响。PDS 的患病率被低估，主要是由于其轻微的临床症状。尽管 PG 的患病率很低，但与 PG 相关的视力损害却极为严重。PDS-PG 在白种人中的患病率是黑人或亚洲人的四倍或更多倍，长期以来，白种人的“经典”PDS 一直被用作基准诊断标准。在对非洲裔美国人和亚洲人进行广泛研究后，诊断 PDS-PG 的标准得到了改进。同时，不同种族PDS的发病机制也不尽相同。因此，预防性治疗的有效性和治疗的需要在不同种族中未必相同。PDS 向 PG 的转化率在高加索人中接近 1/3，在黑人和亚洲人中更高，需要更积极的治疗和监测。我们系统地搜索了一个 PubMed 数据库，从开始到 2022 年 3 月，以概述 PDS-PG 各个方面的研究进展。具体而言，本文综合考虑种族对疾病患病率、临床表现、诊断标准、发病机制、遗传性状、治疗和预防的影响，为不同种族PDS-PG的诊治提供准确、全面的指导。我们系统地搜索了一个 PubMed 数据库，从开始到 2022 年 3 月，以概述 PDS-PG 各个方面的研究进展。具体而言，本文综合考虑种族对疾病患病率、临床表现、诊断标准、发病机制、遗传性状、治疗和预防的影响，为不同种族PDS-PG的诊治提供准确、全面的指导。我们系统地搜索了一个 PubMed 数据库，从开始到 2022 年 3 月，以概述 PDS-PG 各个方面的研究进展。具体而言，本文综合考虑种族对疾病患病率、临床表现、诊断标准、发病机制、遗传性状、治疗和预防的影响，为不同种族PDS-PG的诊治提供准确、全面的指导。