Recent advances in the cascade reactions of enynols/diynols for the synthesis of carbo- and heterocycles,Organic Chemistry Frontiers

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Recent advances in the cascade reactions of enynols/diynols for the synthesis of carbo- and heterocycles
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2022-09-09 , DOI: 10.1039/d2qo01154a
Shimin Jiang ₁ , Haojie Ma ₂ , Ruchun Yang ₁ , Xian-Rong Song ₁ , Qiang Xiao ₁

Affiliation

Carbo- and heterocycles frequently serve as crucial scaffolds in drugs, natural products, fine chemicals, and biologically and pharmaceutically active compounds. Consequently, the development of general, practical, and efficient synthetic approaches for their preparation has attracted considerable attention from organic chemists. In the past few decades, the cascade cyclization of enynols and diynols has become a powerful tool to construct various frameworks. In this review, we highlight recent advances in this field toward the efficient construction of carbo- and heterocycles. According to the type of substrates, these transformations can be divided into two categories: (1) cascade reactions of enynols for the synthesis of carbo- and heterocycles; and (2) cascade reactions of diynols for the synthesis of carbo- and heterocycles.

中文翻译：

用于合成碳环和杂环的烯醇/二炔醇级联反应的最新进展

碳环和杂环经常充当药物、天然产物、精细化学品以及生物和药物活性化合物中的关键支架。因此，开发用于制备它们的通用、实用和高效的合成方法引起了有机化学家的极大关注。在过去的几十年里，烯醇和二炔醇的级联环化已成为构建各种框架的有力工具。在这篇综述中，我们重点介绍了该领域在高效构建碳环和杂环方面的最新进展。根据底物的类型，这些转化可分为两类：（1）烯醇级联反应合成碳环和杂环；(2) 用于合成碳环和杂环的二炔醇的级联反应。

更新日期：2022-09-09

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