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Smart Multifunctional UiO-66 Metal–Organic Framework Nanoparticles with Outstanding Drug-Loading/Release Potential for the Targeted Delivery of Quercetin
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2022-09-08 , DOI: 10.1021/acs.inorgchem.2c00743
Mozhgan Parsaei 1 , Kamran Akhbari 1
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2022-09-08 , DOI: 10.1021/acs.inorgchem.2c00743
Mozhgan Parsaei 1 , Kamran Akhbari 1
Affiliation
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Herein, UiO-66 and its two functional analogs (with −NO2 and −NH2 functional groups) were synthesized, and their potential ability as pH stimulus nanocarriers of quercetin (QU), an anticancer agent, was studied. UiO-66 is a low-toxicity, biocompatible metal–organic framework with a large surface area and good stability, which can be prepared through a facile and inexpensive method. Before and after drug loading, various analyses were conducted to characterize the synthesized nanocarriers. Moreover, Monte Carlo simulations were performed to investigate their structures and interactions with quercetin. The most promising drug loading potential and prolonged drug release (over 25 days) were observed in QU@UiO-66-NO2 with 37% drug loading content, which was the best-tested sample that exhibited a higher release rate under acidic conditions (pH = 5) than that in normal cells (pH = 7.4). This behavior is known as pH-stimulus-controlled ability. The cell treatment with free QU, UiO-66-R, and QU@UiO-66-R (R = −H, −NO2, and −NH2) was performed, and an MTT assay was conducted on HEK-293 and MDA-MB-231 cells for the cytotoxicity study. Additionally, the kinetic modeling of drug release was investigated on the basis of the analysis of the drug release profiles.
中文翻译：
智能多功能 UiO-66 金属-有机骨架纳米粒子具有出色的载药/释放潜力，可用于槲皮素的靶向递送
在此，合成了UiO-66及其两种功能类似物（具有-NO 2和-NH 2官能团），并研究了它们作为抗癌剂槲皮素（QU）的pH刺激纳米载体的潜在能力。UiO-66是一种低毒、生物相容的金属有机骨架，具有大的比表面积和良好的稳定性，可以通过简便、廉价的方法制备。在载药前后，进行了各种分析以表征合成的纳米载体。此外，进行蒙特卡罗模拟以研究它们的结构和与槲皮素的相互作用。在 QU@UiO-66-NO 2中观察到最有希望的载药潜力和延长药物释放时间（超过 25 天）载药量为 37%，这是经过最佳测试的样品，在酸性条件 (pH = 5) 下比在正常细胞 (pH = 7.4) 中表现出更高的释放率。这种行为被称为 pH 刺激控制能力。用游离 QU、UiO-66-R 和 QU@UiO-66-R（R = -H、-NO 2和 -NH 2）进行细胞处理，并在 HEK-293 和MDA-MB-231 细胞用于细胞毒性研究。此外，在药物释放曲线分析的基础上研究了药物释放的动力学模型。
更新日期：2022-09-08
中文翻译：
智能多功能 UiO-66 金属-有机骨架纳米粒子具有出色的载药/释放潜力，可用于槲皮素的靶向递送
在此，合成了UiO-66及其两种功能类似物（具有-NO 2和-NH 2官能团），并研究了它们作为抗癌剂槲皮素（QU）的pH刺激纳米载体的潜在能力。UiO-66是一种低毒、生物相容的金属有机骨架，具有大的比表面积和良好的稳定性，可以通过简便、廉价的方法制备。在载药前后，进行了各种分析以表征合成的纳米载体。此外，进行蒙特卡罗模拟以研究它们的结构和与槲皮素的相互作用。在 QU@UiO-66-NO 2中观察到最有希望的载药潜力和延长药物释放时间（超过 25 天）载药量为 37%，这是经过最佳测试的样品，在酸性条件 (pH = 5) 下比在正常细胞 (pH = 7.4) 中表现出更高的释放率。这种行为被称为 pH 刺激控制能力。用游离 QU、UiO-66-R 和 QU@UiO-66-R（R = -H、-NO 2和 -NH 2）进行细胞处理，并在 HEK-293 和MDA-MB-231 细胞用于细胞毒性研究。此外，在药物释放曲线分析的基础上研究了药物释放的动力学模型。
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