Diverse Flavonoids from the Roots of Indigofera stachyodes,Chemistry & Biodiversity

当前位置： X-MOL 学术 › Chem. Biodivers. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Diverse Flavonoids from the Roots of Indigofera stachyodes
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2022-09-07 , DOI: 10.1002/cbdv.202200676
Huayong Lou _{1,

2} , Hanfei Liu _{1,

2} , Huan Wang ₁ , Yumin Zhao ₃ , Lei Huang _{1,

2} , Jian Fu ₃ , Xiaojiang Hao _{1,

2} , Weidong Pan _{1,

2}

Affiliation

Three new flavonoids, 4′-O-β-D-glucopyranosyl-2S,3R-3,7-dihydroxy-3′-methoxyflavan (1), (3R)-7,4′-dihydroxy-5,3′-methoxychalcone (2), (3S)-7,2′,3′-trihydroxy-6,4′-dimethoxylisoflavan (3), and one new natural occurring product, (3S)-6,2′,3′-trihydroxy-7,4′-dimethoxylisoflavan (4), together with eleven known ones (5–15), were isolated from the roots of Indigofera stachyodes. The structures of these compounds were confirmed by UV, IR, MS, and NMR spectroscopic analysis. The absolute configurations of new compounds were elucidated by ECD spectra and chemical method. All the isolated flavonoids were screened for their antioxidant abilities to scavenge DPPH and ABTS⁺. As results, compounds 2–4, 10, and 15 exhibited remarkable scavenging activity against both ABTS⁺ and DPPH, with the IC₅₀ values less than 20 μM. In addition, compounds 1, 6–9, and 13 exhibited potential antioxidant scavenging activities, IC₅₀ values were in the range of 17.96∼85.91 μM.

中文翻译：

来自 Indigofera stachyodes 根的多种黄酮类化合物

三种新型黄酮类化合物，4'- O - β -D-吡喃葡萄糖基-2 S ,3 R -3,7-dihydroxy-3'-methoxyflavan ( 1 ), (3 R )-7,4'-dihydroxy-5,3 '-甲氧基查耳酮 ( 2 ), (3 S )-7,2',3'-trihydroxy-6,4'-二甲氧基异黄烷 ( 3 ) 和一种新的天然产物 (3 S )-6,2',3 '-trihydroxy-7,4'-dimethoxylisoflavan ( 4 ) 和 11 个已知的 ( 5-15 )是从Indigofera stachyodes的根中分离出来的. 这些化合物的结构通过紫外、红外、质谱和核磁共振光谱分析得到证实。通过ECD光谱和化学方法阐明了新化合物的绝对构型。^{筛选所有分离的黄酮类化合物清除 DPPH 和 ABTS +}的抗氧化能力。结果，化合物2-4、10和15对ABTS ^+和DPPH均表现出显着的清除活性，IC ₅₀值小于 20 μM 。此外，化合物1、6 – 9和13表现出潜在的抗氧化清除活性，IC ₅₀值在 17.96∼85.91 μM 范围内。

更新日期：2022-09-07

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南