Methylmercury (MeHg⁺) is one of the common organic species of mercury, and has much higher toxicity than inorganic mercury. Based on the selective enhancement of the activity of nanozyme (NA-CDs/AuNPs) by MeHg⁺, a novel colorimetric nanoprobe for MeHg⁺ assay is proposed. The noradrenaline-based carbon dots (NA-CDs) as the reducing agent was applied to prepare the NA-CDs/AuNPs. The formation of gold amalgamation (Au@HgNPs) between nanozyme and MeHg⁺ allows to simultaneously accelerate the electron transfer from Au and Hg to NA-CDs and the generation of radicals (i.e. ∙OH, ∙O₂^- and ∙CH₃). The NA-CDs/AuNPs has an outstanding anti-interference performance even in the presence of different mercury. Further density functionality theory (DFT) calculations revealed that the formation of Au@HgNPs via MeHg⁺ contributes to the significantly lowered activation energy, resulting in the peroxidase-like activity generation and acceleration. This leads to rapid (10 min) and specific colorimetric detection of MeHg⁺ with the detection limit of 0.06 μg L⁻¹. This introduces a novel method for simple and sensitive detection of MeHg⁺, giving a new horizon for the assay of organometallic compounds.

甲基汞 (MeHg ⁺ ) 是常见的有机汞之一，其毒性远高于无机汞。基于MeHg + 对纳米酶（NA-CDs/AuNPs）活性的选择性增强，提出了^{一种用于MeHg +测定}的新型比色纳米探针。应用去甲肾上腺素基碳点 (NA-CDs) 作为还原剂来制备 NA-CDs/AuNPs。^{纳米酶和 MeHg +}之间的金融合 (Au@HgNPs) 的形成允许同时加速从 Au 和 Hg 到 NA-CDs 的电子转移和自由基（即 ∙OH、∙O ₂ ^-和 ∙CH ₃）。即使在不同的汞存在下，NA-CDs/AuNPs 也具有出色的抗干扰性能。进一步的密度泛函理论 (DFT) 计算表明，通过 MeHg ⁺形成 Au@HgNPs有助于显着降低活化能，从而导致过氧化物酶样活性的产生和加速。这导致对 MeHg ⁺的快速（10 分钟）和特异性比色检测，检测限为 0.06 μg L ^-1。这介绍了一种简单而灵敏地检测 MeHg ⁺的新方法，为有机金属化合物的测定提供了新的视野。