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Effect of the harvest period on the structure and anti-allergic activity of Porphyra haitanensis polysaccharides
Food & Function ( IF 5.1 ) Pub Date : 2022-09-07 , DOI: 10.1039/d2fo01442d Chong Wang 1 , Ziqiang Ye 1 , Yanbo Wang 1 , Linglin Fu 1
Food & Function ( IF 5.1 ) Pub Date : 2022-09-07 , DOI: 10.1039/d2fo01442d Chong Wang 1 , Ziqiang Ye 1 , Yanbo Wang 1 , Linglin Fu 1
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Polysaccharides are a major functional component of seaweeds with various biological activities. Porphyra haitanensis is usually harvested in different growth periods, but how the harvest periods influence the Porphyra haitanensis polysaccharide (PHP) activity is unclear. This work aimed to evaluate the anti-allergic activity of PHP from different harvest periods and investigate the potential structure–activity relationship. The water-soluble polysaccharide of P. haitanensis from three different harvest periods was purified and administered to an ovalbumin-sensitized food allergy mouse model. Results showed that PHPs significantly alleviated the allergic symptoms and reduced the production of histamine and allergen-specific IgE. Further experiments elucidated that PHPs suppressed the allergic activity of intestinal epithelial cells, dendritic cells, and Th2 cells and downregulated the proportion of Th2 cells. Noticeably, the molecular weight and sulfate content gradually decreased as the harvest period was delayed; simultaneously, the anti-allergic activity gradually increased, implying a relationship between the harvest period, structure, and anti-allergic activity of PHPs. This work elucidated the anti-allergic activity of PHPs from different harvest periods, facilitated the deep-processing and efficient application of Porphyra haitanensis, and shed light on the development of novel anti-allergic functional foods.
中文翻译：
采收期对紫菜多糖结构及抗过敏活性的影响
多糖是海藻的主要功能成分，具有多种生物活性。紫菜通常在不同的生长期收获，但收获期如何影响紫菜多糖（PHP）活性尚不清楚。本工作旨在评估不同收获期 PHP 的抗过敏活性，并研究潜在的构效关系。地瓜水溶性多糖来自三个不同收获期的纯化并施用于卵白蛋白致敏的食物过敏小鼠模型。结果表明，PHPs 可显着缓解过敏症状并减少组胺和过敏原特异性 IgE 的产生。进一步的实验表明，PHPs抑制了肠上皮细胞、树突状细胞和Th2细胞的过敏活性，并下调了Th2细胞的比例。值得注意的是，随着采收期的推迟，分子量和硫酸盐含量逐渐下降；同时，抗过敏活性逐渐增加，表明 PHPs 的收获期、结构和抗过敏活性之间存在关系。这项工作阐明了不同收获期 PHPs 的抗过敏活性，紫菜，为新型抗过敏功能食品的开发提供启示。
更新日期：2022-09-07
中文翻译：
采收期对紫菜多糖结构及抗过敏活性的影响
多糖是海藻的主要功能成分，具有多种生物活性。紫菜通常在不同的生长期收获，但收获期如何影响紫菜多糖（PHP）活性尚不清楚。本工作旨在评估不同收获期 PHP 的抗过敏活性，并研究潜在的构效关系。地瓜水溶性多糖来自三个不同收获期的纯化并施用于卵白蛋白致敏的食物过敏小鼠模型。结果表明，PHPs 可显着缓解过敏症状并减少组胺和过敏原特异性 IgE 的产生。进一步的实验表明，PHPs抑制了肠上皮细胞、树突状细胞和Th2细胞的过敏活性，并下调了Th2细胞的比例。值得注意的是，随着采收期的推迟，分子量和硫酸盐含量逐渐下降；同时，抗过敏活性逐渐增加，表明 PHPs 的收获期、结构和抗过敏活性之间存在关系。这项工作阐明了不同收获期 PHPs 的抗过敏活性，紫菜，为新型抗过敏功能食品的开发提供启示。
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