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Osthole: An up-to-date review of its anticancer potential and mechanisms of action
Frontiers in Pharmacology ( IF 4.4 ) Pub Date : 2022-09-07 , DOI: 10.3389/fphar.2022.945627
Shaojie Yang 1 , Wanlin Dai 2 , Jingnan Wang 1 , Xiaolin Zhang 1 , Yuting Zheng 1 , Shiyuan Bi 1 , Liwei Pang 3 , Tengqi Ren 4 , Ye Yang 1 , Yang Sun 1 , Zhuyuan Zheng 1 , Shuodong Wu 1 , Jing Kong 1
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With its high incidence and mortality rates, cancer is one of the largest health problems worldwide. Investigating various cancer treatment options has been the focus of many domestic and international researchers, and significant progress has been made in the study of the anticancer effects of traditional Chinese medicines. Osthole, a coumarin compound extracted from Cnidium monnieri (L.) Cuss., has become a new research hotspot. There have been many reports on its anticancer effects, and recent studies have elucidated that its underlying mechanism of action mainly involves inhibiting cancer cell proliferation, inducing cancer cell apoptosis, inhibiting invasion and migration of cancer cells, inhibiting cancer angiogenesis, increasing sensitivity to chemotherapy drugs, and reversing multidrug resistance of cancer cells. This mini-review summarizes the research progress on the anticancer effects of osthole in recent years.



中文翻译:

蛇床子素:对其抗癌潜力和作用机制的最新回顾

由于其高发病率和死亡率,癌症是全球最大的健康问题之一。研究各种癌症治疗方案一直是国内外众多研究人员关注的焦点,中药抗癌作用的研究也取得了重大进展。蛇床子素,一种从植物中提取的香豆素化合物蛇床子 (L.) Cuss.,已成为新的研究热点。其抗癌作用已有很多报道,近期研究阐明其潜在作用机制主要包括抑制癌细胞增殖、诱导癌细胞凋亡、抑制癌细胞侵袭和迁移、抑制癌血管生成、增加对化疗药物的敏感性。 ,并逆转癌细胞的多药耐药性。本篇小评总结了近年来蛇床子素抗癌作用的研究进展。

更新日期:2022-09-07
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