Inflammation Research ( IF 4.8 ) Pub Date : 2022-09-05 , DOI: 10.1007/s00011-022-01607-w Lingyu Zhong 1 , Qiao Peng 1 , Xun Zeng 1
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Background
Adenosine, acting as a regulator by mediating the activation of G protein-coupled adenosine receptor families (A1, A2A, A2B, and A3), plays an important role under physiological and pathological conditions. As the receptor with the highest affinity for adenosine, the role of adenosine A1 receptor (A1R)-mediated adenosine signaling pathway in the central nervous system has been well addressed. However, functions of A1R on immune cells are less summarized. Considering that some immune cells express multiple types of adenosine receptors with distinct effects and varied density, exogenous adenosine of different concentrations may induce divergent immune cell functions.
Materials and methods
The literatures about the expression of A1R and its regulation on immune cells and how it regulates the function of immune cells were searched on PubMed and Google Scholar.
Conclusion
In this review, we discussed the effects of A1R on immune cells, including monocytes, macrophages, neutrophils, dendritic cells, and microglia, and focused on the role of A1R in regulating immune cells in diseases, which may facilitate our understanding of the mechanisms by which adenosine affects immune cells through A1R.
中文翻译：
腺苷A1受体对免疫细胞的作用
背景
腺苷作为调节剂通过介导 G 蛋白偶联腺苷受体家族（A 1、A 2 A、A 2 B 和 A 3）的激活而在生理和病理条件下发挥重要作用。作为对腺苷亲和力最高的受体，腺苷A 1受体(A 1 R) 介导的腺苷信号通路在中枢神经系统中的作用已得到很好的解决。然而，A 1的功能R对免疫细胞的总结较少。考虑到一些免疫细胞表达多种类型的腺苷受体，作用不同，密度不同，不同浓度的外源性腺苷可能诱导不同的免疫细胞功能。
材料和方法
在PubMed和Google Scholar上检索了关于A 1 R 的表达及其对免疫细胞的调节及其如何调节免疫细胞功能的文献。
结论
在这篇综述中，我们讨论了 A 1 R 对免疫细胞（包括单核细胞、巨噬细胞、中性粒细胞、树突细胞和小胶质细胞）的影响，并重点讨论了 A 1 R 在调节免疫细胞在疾病中的作用，这可能有助于我们理解腺苷通过 A 1 R影响免疫细胞的机制。
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