Composite glass systems without SiO₂ have attracted research interest to solve the challenges associated with SiO₂ glass-based bioactive materials. Herein, we synthesized phosphate glass composites, which involves CaO–ZnO–P₂O₅ glass (composed of orthophosphate (Q⁰) or pyrophosphate (Q¹) groups)) and a small amount of P₂O₅ glass (composed of metaphosphate (Q²) groups), by melt quenching. The effects of the added P₂O₅ glass content on the in vitro bioactivity were then investigated. From the simulated body fluid (SBF) test, the maximum weight gain values were obtained regardless of the base glass, and spherical precipitates were observed on the sample surface with 2 wt.% added P₂O₅ by SEM. The addition of ≥ 3 wt.% P₂O₅ glass decreased the weight gain, retained the structure of the sample, and increased the size of the spherical precipitates. The spherical precipitates were Ca–Zn phosphate compounds presumed by XRD analysis to be a mixture of Ca–Zn hydroxyapatite and parascholzite. Among the samples comprising P₂O₅ glass, the Q⁰ group glass-based composites exhibited larger weight gain than the Q¹ group glass-based composites. Therefore, three factors are crucial in the precipitation and growth of phosphate compounds on the sample surface in the in vitro test: (1) promoted dissolution of the P component in the SBF solution; (2) increased abundance of Q⁰, which is the starting point of precipitation; and (3) co-existence of dissolution and precipitation in separate glasses.

_{不含 SiO 2}的复合玻璃系统已引起研究兴趣，以解决与 SiO ₂玻璃基生物活性材料相关的挑战。在此，我们合成了磷酸盐玻璃复合材料，其中包括CaO-ZnO-P ₂ O ₅玻璃（由正磷酸盐（Q ⁰）或焦磷酸盐（Q ¹）基团组成）和少量的P ₂ O ₅玻璃（由偏磷酸盐组成） (Q ² ) 基团)，通过熔融淬火。添加 P ₂ O _5的效果然后研究了玻璃含量对体外生物活性的影响。从模拟体液 (SBF) 测试中，无论基体玻璃如何，都获得了最大重量增加值，并且通过 SEM在添加 2 wt.% P ₂ O _{5的样品表面上观察到球形沉淀物。}添加≥ 3 wt.% P ₂ O ₅玻璃降低了重量增加，保留了样品的结构，并增加了球形沉淀物的尺寸。球形沉淀物是钙锌磷酸盐化合物，通过 XRD 分析推测是钙锌羟基磷灰石和磷钾钙石的混合物。在包含 P ₂ O ₅玻璃的样品中，Q ⁰组玻璃基复合材料的增重大于 Q ¹组玻璃基复合材料。因此，在体外试验中，三个因素对磷酸盐化合物在样品表面的沉淀和生长至关重要：（1）促进 P 组分在 SBF 溶液中的溶解；(2) Q ⁰丰度增加，这是降水的起点；(3) 在不同的玻璃杯中溶解和沉淀共存。