氧化石墨烯作为生物相容性和骨诱导剂促进兔胫骨模型中的植入物骨整合,Advanced Materials Interfaces

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氧化石墨烯作为生物相容性和骨诱导剂促进兔胫骨模型中的植入物骨整合
Advanced Materials Interfaces ( IF 4.3 ) Pub Date : 2022-09-04 , DOI: 10.1002/admi.202201116
Jeong Min Kwak ₁ , Jungho Kim ₂ , Chung‐Sung Lee _{3,

4} , Il‐Soo Park ₂ , Min Lee _{3,

5} , Dal‐Hee Min _{2,

6,

7} , In‐Sung Luke Yeo ₁

Affiliation

^{石墨烯，一种由 sp 2}制成的纳米材料最近研究了杂化碳原子作为促进骨整合的新型表面处理。本研究旨在评估氧化石墨烯 (GO) 对车削和喷砂、大粒度和酸蚀 (SLA) 钛表面的生物效应。在体外，将骨髓基质细胞 (BMSCs) 和人牙龈成纤维细胞 (HGFs) 接种到钛圆盘上，钛圆盘的表面经过四种不同的处理方式（SLA 和/或 GO），以观察其对细胞反应的影响，例如粘附，增殖和分化。在体内，使用兔胫骨模型观察四种表面处理对螺旋形钛植入物骨整合的影响。使用光学显微镜组织形态学分析骨与植入物的接触。GO显着促进了生存能力，BMSCs 的增殖和成骨细胞分化，增强 HGFs 的附着和增殖。植入物表面的 SLA 和 GO 处理可显着改善体内骨整合。通过 SLA 处理和 GO 涂层对钛表面进行物理化学改性可刺激间充质干细胞的成骨活性并提高与结缔组织细胞的生物相容性，从而促进骨-植入物界面处的骨愈合。

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Graphene Oxide as a Biocompatible and Osteoinductive Agent to Promote Implant Osseointegration in a Rabbit Tibia Model

Graphene, a nanomaterial made of sp² hybridized carbon atoms, has recently been investigated as a novel surface treatment for promoting osseointegration. This study aims to evaluate the biological effects of graphene oxide (GO) on turned and sandblasted, large-grit, and acid-etched (SLA) titanium surfaces. In vitro, bone marrow stromal cells (BMSCs) and human gingival fibroblasts (HGFs) are seeded onto titanium discs, whose surfaces have been treated in four different ways (SLA and/or GO), to observe its effects on cellular responses such as adhesion, proliferation and differentiation. In vivo, a rabbit tibia model is used to observe the effects of the four surface treatments on osseointegration of screw-shaped titanium implants. The bone-to-implant contact is analyzed using light microscopic histomorphometry. GO significantly promotes the viability, proliferation and osteoblast differentiation of BMSCs, and it enhances the attachment and proliferation of HGFs. SLA and GO treatment of implant surfaces results in significant improvement of osseointegration in vivo. Physicochemical modification of the titanium surface by SLA treatment and GO coating stimulates osteogenic activities of mesenchymal stem cells and improves biocompatibility to connective tissue cells, leading to enhancement of bone healing at the bone-implant interface.

更新日期：2022-09-04

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