Wound ulceration caused by diabetes is a typical chronic wound wherein healing the local tissue is difficult due to lack of blood vessels and tissue necrosis caused by the long-term accumulation of free radicals. Near-field electrospinning (NFES) is an innovative technology used to produce micro-nano-scaled, controllable sequencing fibers. In this study, we constructed a novel wound dressing based on the NFES polycaprolactone (PCL) fiber network and modified gelatin with methacrylic anhydride (GelMA) hydrogel to promote angiogenesis and the re-epithelialization of diabetic wounds. An angiogenic and antioxidant drug named deferoxamine (DFO) was encapsulated in a GelMA hydrogel to achieve a slow-release effect that is more suitable for chronic wounds. The cell adhesion experiment showed that the cells could attach to the fibers in the dressing group having a network of PCL fibers on the surface and grow along the direction of the fibers, which in turn, effectively regulates cell behavior from the physical structure. Additionally, the large pore size (∼ 500 µm) of the network allowed the cells to penetrate the pores and enter the surface of the hydrogel without being blocked out. Besides, the composite dressing had a notable effect on angiogenesis. Furthermore, antioxidation experiments confirmed that the DFO-loaded hydrogel exhibited antioxidant activity. Experimental animal models of diabetes showed that rats treated with the PCL-GelMA-DFO (PGD) hydrogel had faster ability of hemostasis, scab formation, and wound healing. In conclusion, the PGD hydrogel effectively promoted the repair of chronic wounds.

糖尿病引起的创面溃疡是一种典型的慢性创面，由于长期积累的自由基导致组织坏死、血管缺乏，局部组织难以愈合。近场静电纺丝 (NFES) 是一种用于生产微纳米级可控测序纤维的创新技术。在这项研究中，我们构建了一种基于 NFES 聚己内酯 (PCL) 纤维网络和甲基丙烯酸酐 (GelMA) 水凝胶改性明胶的新型伤口敷料，以促进糖尿病伤口的血管生成和再上皮化。一种名为去铁胺 (DFO) 的血管生成和抗氧化药物被封装在 GelMA 水凝胶中，以实现更适合慢性伤口的缓释效果。细胞粘附实验表明，敷料组的细胞可以附着在表面具有PCL纤维网络的纤维上，并沿着纤维的方向生长，从而有效地从物理结构上调节细胞行为。此外，网络的大孔径（~500 µm）允许细胞穿透孔隙并进入水凝胶表面而不会被阻挡。此外，复合敷料对血管生成有显着影响。此外，抗氧化实验证实负载 DFO 的水凝胶具有抗氧化活性。糖尿病实验动物模型表明，用 PCL-GelMA-DFO (PGD) 水凝胶治疗的大鼠具有更快的止血、结痂和伤口愈合能力。综上所述，