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Stimuli-Responsive Aggregation-Induced Emission (AIE)-Active Polymers for Biomedical Applications
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2022-09-02 , DOI: 10.1021/acsbiomaterials.2c00656 Pampa Chowdhury 1 , Arnab Banerjee 1 , Biswajit Saha 1 , Kamal Bauri 2 , Priyadarsi De 1
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2022-09-02 , DOI: 10.1021/acsbiomaterials.2c00656 Pampa Chowdhury 1 , Arnab Banerjee 1 , Biswajit Saha 1 , Kamal Bauri 2 , Priyadarsi De 1
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At high concentration or in the aggregated state, most of the traditional luminophores suffer from the general aggregation-caused quenching (ACQ) effect, which significantly limits their biomedical applications. On the contrary, a few fluorophores exhibit an aggregation-induced emission (AIE) feature which is just the opposite of ACQ. The luminophores with aggregation-induced emission (AIEgens) have exhibited noteworthy advantages to get tunable emission, excellent photostability, and biocompatibility. Incorporating AIEgens into polymer design has yielded diversified polymer systems with fascinating photophysical characteristics. Again, stimuli-responsive polymers are capable of undergoing chemical and/or physical property changes on receiving signals from single or multiple stimuli. The combination of the AIE property and stimuli responses in a single polymer platform provides a feasible and effective strategy for the development of smart polymers with promising biomedical applications. Herein, the advancements in stimuli-responsive polymers with AIE characteristics for biomedical applications are summarized. AIE-active polymers are first categorized into conventional π–π conjugated and nonconventional fluorophore systems and then subdivided based on various stimuli, such as pH, redox, enzyme, reactive oxygen species (ROS), and temperature. In each section, the design strategies of the smart polymers and their biomedical applications, including bioimaging, cancer theranostics, gene delivery, and antimicrobial examples, are introduced. The current challenges and future perspectives of this field are also stated at the end of this review article.
中文翻译：
刺激响应聚集诱导发光 (AIE) - 用于生物医学应用的活性聚合物
在高浓度或聚集状态下，大多数传统发光体都存在一般的聚集引起的猝灭（ACQ）效应，这极大地限制了它们在生物医学上的应用。相反，少数荧光团表现出聚集诱导发光 (AIE) 特征，这与 ACQ 正好相反。具有聚集诱导发光的发光体（AIEgens）在获得可调谐发光、优异的光稳定性和生物相容性方面表现出显着优势。将 AIEgens 纳入聚合物设计已经产生了具有迷人光物理特性的多样化聚合物系统。同样，刺激响应聚合物能够在接收到来自单个或多个刺激的信号时发生化学和/或物理性质的变化。将 AIE 特性和刺激响应结合在单个聚合物平台中，为开发具有前景的生物医学应用的智能聚合物提供了一种可行且有效的策略。在此，总结了具有 AIE 特性的刺激响应聚合物在生物医学应用中的进展。AIE 活性聚合物首先分为传统的 π-π 共轭和非常规荧光团系统，然后根据各种刺激因素进行细分，例如 pH、氧化还原、酶、活性氧 (ROS) 和温度。在每一节中，介绍了智能聚合物的设计策略及其生物医学应用，包括生物成像、癌症治疗、基因传递和抗菌实例。
更新日期：2022-09-02
中文翻译：
刺激响应聚集诱导发光 (AIE) - 用于生物医学应用的活性聚合物
在高浓度或聚集状态下，大多数传统发光体都存在一般的聚集引起的猝灭（ACQ）效应，这极大地限制了它们在生物医学上的应用。相反，少数荧光团表现出聚集诱导发光 (AIE) 特征，这与 ACQ 正好相反。具有聚集诱导发光的发光体（AIEgens）在获得可调谐发光、优异的光稳定性和生物相容性方面表现出显着优势。将 AIEgens 纳入聚合物设计已经产生了具有迷人光物理特性的多样化聚合物系统。同样，刺激响应聚合物能够在接收到来自单个或多个刺激的信号时发生化学和/或物理性质的变化。将 AIE 特性和刺激响应结合在单个聚合物平台中，为开发具有前景的生物医学应用的智能聚合物提供了一种可行且有效的策略。在此，总结了具有 AIE 特性的刺激响应聚合物在生物医学应用中的进展。AIE 活性聚合物首先分为传统的 π-π 共轭和非常规荧光团系统，然后根据各种刺激因素进行细分，例如 pH、氧化还原、酶、活性氧 (ROS) 和温度。在每一节中，介绍了智能聚合物的设计策略及其生物医学应用，包括生物成像、癌症治疗、基因传递和抗菌实例。
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