Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides,Chemical Reviews

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Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides
Chemical Reviews ( IF 51.4 ) Pub Date : 2022-09-01 , DOI: 10.1021/acs.chemrev.2c00210
Chayanid Ongpipattanakul , Emily K Desormeaux , Adam DiCaprio , Wilfred A van der Donk ₁ , Douglas A Mitchell ₁ , Satish K Nair ₁

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Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural product class that has undergone significant expansion due to the rapid growth in genome sequencing data and recognition that they are made by biosynthetic pathways that share many characteristic features. Their mode of actions cover a wide range of biological processes and include binding to membranes, receptors, enzymes, lipids, RNA, and metals as well as use as cofactors and signaling molecules. This review covers the currently known modes of action (MOA) of RiPPs. In turn, the mechanisms by which these molecules interact with their natural targets provide a rich set of molecular paradigms that can be used for the design or evolution of new or improved activities given the relative ease of engineering RiPPs. In this review, coverage is limited to RiPPs originating from bacteria.

中文翻译：

核糖体合成和翻译后修饰肽的作用机制

核糖体合成和翻译后修饰肽 (RiPP) 是一类天然产物，由于基因组测序数据的快速增长以及人们认识到它们是由具有许多共同特征的生物合成途径产生的，因此该类天然产物已经历了显着的扩展。它们的作用模式涵盖广泛的生物过程，包括与膜、受体、酶、脂质、RNA 和金属的结合以及用作辅助因子和信号分子。本综述涵盖了 RiPP 目前已知的作用模式 (MOA)。反过来，这些分子与其天然靶标相互作用的机制提供了一套丰富的分子范式，考虑到 RiPP 的工程设计相对容易，这些范式可用于设计或进化新的或改进的活性。在本综述中，覆盖范围仅限于源自细菌的 RiPP。

更新日期：2022-09-01

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