Rose Bengal (RB) is a photosensitizer (PS) used in anti-cancer and anti-bacterial photodynamic therapy (PDT). The specific excitation of this PS allows the production of singlet oxygen and oxygen reactive species that kill bacteria and tumor cells. In this review, we summarize the history of the use of RB as a PS coupled by chemical or physical means to nanoparticles (NPs). The studies are divided into PDT and PDT excited by X-rays (X-PDT), and subdivided on the basis of NP type. On the basis of the papers examined, it can be noted that RB used as a PS shows remarkable cytotoxicity under the effect of light, and RB loaded onto NPs is an excellent candidate for nanomedical applications in PDT and X-PDT.

中文翻译：

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负载有纳米粒子的玫瑰红在抗癌光动力治疗中的重要性

玫瑰红 (RB) 是一种用于抗癌和抗菌光动力疗法 (PDT) 的光敏剂 (PS)。这种 PS 的特定激发允许产生杀死细菌和肿瘤细胞的单线态氧和氧活性物质。在这篇综述中，我们总结了使用 RB 作为 PS 通过化学或物理方式与纳米粒子 (NPs) 耦合的历史。研究分为PDT和X射线激发的PDT（X-PDT），并根据NP类型细分。根据所审查的论文，可以注意到用作 PS 的 RB 在光的作用下表现出显着的细胞毒性，负载到 NPs 上的 RB 是 PDT 和 X-PDT 中纳米医学应用的优秀候选者。