CD36, located on the cell membrane, transports fatty acids in response to dietary fat. It is a critical fatty acid sensor and regulator of lipid metabolism. The interaction between CD36 and lipid dysmetabolism and obesity has been identified in various models and human studies. Nevertheless, the mechanisms by which CD36 regulates lipid metabolism and the role of CD36 in metabolic diseases remain obscure. Here, we summarize the latest research on the role of membrane CD36 in fat metabolism, with emphasis on CD36-mediated fat sensing and transport. This review also critically discusses the factors affecting the regulation of CD36-mediated fat dysfunction. Finally, we review previous clinical evidence of CD36 in metabolic diseases and consider the path forward.

位于细胞膜上的 CD36 转运脂肪酸以响应膳食脂肪。它是脂质代谢的关键脂肪酸传感器和调节剂。CD36 与脂质代谢障碍和肥胖之间的相互作用已在各种模型和人体研究中得到证实。尽管如此，CD36调节脂质代谢的机制以及CD36在代谢性疾病中的作用仍不清楚。在这里，我们总结了膜CD36在脂肪代谢中的作用的最新研究，重点是CD36介导的脂肪传感和运输。这篇综述还批判性地讨论了影响 CD36 介导的脂肪功能障碍调节的因素。最后，我们回顾了 CD36 在代谢性疾病中的先前临床证据，并考虑了前进的道路。