Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Ultrathin Hafnium Disulfide Atomic Crystals with ROS-Scavenging and Colon-Targeting Capabilities for Inflammatory Bowel Disease Treatment
ACS Nano ( IF 15.8 ) Pub Date : 2022-08-29 , DOI: 10.1021/acsnano.2c06151 Ruoyao Li 1 , Yuanyuan Fan 2, 3 , Lulu Liu 1 , Hongna Ma 1 , Deyan Gong 1 , Zhaohua Miao 1, 4 , Hua Wang 2, 3 , Zhengbao Zha 1
ACS Nano ( IF 15.8 ) Pub Date : 2022-08-29 , DOI: 10.1021/acsnano.2c06151 Ruoyao Li 1 , Yuanyuan Fan 2, 3 , Lulu Liu 1 , Hongna Ma 1 , Deyan Gong 1 , Zhaohua Miao 1, 4 , Hua Wang 2, 3 , Zhengbao Zha 1
Affiliation
|
The exciting success of NBTXR3 in the clinic has triggered a tumult of activities in the design and development of hafnium-based nanoparticles. However, due to the concerns of nondegradation and limited functions, the biomedical applications of Hf-based nanoparticles mainly focus on tumors. Herein, tannic acid capped hafnium disulfide (HfS2@TA) nanosheets, a 2D atomic crystal of hafnium-based materials prepared by liquid-phase exfoliation, were explored as high-performance anti-inflammatory nanoagents for the targeted therapy of inflammatory bowel disease (IBD). Benefiting from the transformation of the S2–/S6+ valence state and huge specific surface area, the obtained HfS2@TA nanosheets were not only capable of effectively eliminating reactive oxygen species/reactive nitrogen species and downregulating pro-inflammatory factors but also could be excreted via kidney and hepatointestinal systems. Unexpectedly, HfS2@TA maintained excellent targeting capability to an inflamed colon even in the harsh digestive tract environment, mainly attributed to the electrostatic interactions between negatively charged tannic acid and positively charged inflamed epithelium. Encouragingly, upon oral or intravenous administration, HfS2@TA quickly inhibited inflammation and repaired the intestinal mucosa barrier in both dextran sodium sulfate and 2,4,6-trinitrobenzenesulfonic acid induced IBD models. This work demonstrated that ultrathin HfS2@TA atomic crystals with enhanced colon accumulation were promising for the targeted therapy of IBD.
中文翻译：
具有清除 ROS 和结肠靶向能力的超薄二硫化铪原子晶体用于炎症性肠病治疗
NBTXR3在临床上的激动人心的成功引发了铪基纳米粒子的设计和开发活动的骚动。然而，由于考虑到不可降解和功能有限，Hf基纳米粒子的生物医学应用主要集中在肿瘤上。在此，单宁酸封端的二硫化铪 ( HfS 2 @TA) 纳米片是一种通过液相剥离制备的铪基材料的二维原子晶体，被探索为用于炎症性肠病靶向治疗的高性能抗炎纳米剂。 IBD）。得益于S 2– /S 6+价态的转变和巨大的比表面积，得到的HfS 2@TA 纳米片不仅能够有效地消除活性氧/活性氮和下调促炎因子，而且还可以通过肾脏和肝肠系统排泄。出乎意料的是，即使在恶劣的消化道环境中，HfS 2 @TA 仍能对发炎的结肠保持出色的靶向能力，这主要归功于带负电荷的单宁酸和带正电荷的发炎上皮细胞之间的静电相互作用。令人鼓舞的是，在口服或静脉内给药后， HfS 2 @TA 在葡聚糖硫酸钠和 2,4,6-三硝基苯磺酸诱导的 IBD 模型中迅速抑制炎症并修复肠粘膜屏障。这项工作表明，超薄 HfS 2具有增强结肠积累的@TA原子晶体有望用于IBD的靶向治疗。
更新日期：2022-08-29
中文翻译：
具有清除 ROS 和结肠靶向能力的超薄二硫化铪原子晶体用于炎症性肠病治疗
NBTXR3在临床上的激动人心的成功引发了铪基纳米粒子的设计和开发活动的骚动。然而，由于考虑到不可降解和功能有限，Hf基纳米粒子的生物医学应用主要集中在肿瘤上。在此，单宁酸封端的二硫化铪 ( HfS 2 @TA) 纳米片是一种通过液相剥离制备的铪基材料的二维原子晶体，被探索为用于炎症性肠病靶向治疗的高性能抗炎纳米剂。 IBD）。得益于S 2– /S 6+价态的转变和巨大的比表面积，得到的HfS 2@TA 纳米片不仅能够有效地消除活性氧/活性氮和下调促炎因子，而且还可以通过肾脏和肝肠系统排泄。出乎意料的是，即使在恶劣的消化道环境中，HfS 2 @TA 仍能对发炎的结肠保持出色的靶向能力，这主要归功于带负电荷的单宁酸和带正电荷的发炎上皮细胞之间的静电相互作用。令人鼓舞的是，在口服或静脉内给药后， HfS 2 @TA 在葡聚糖硫酸钠和 2,4,6-三硝基苯磺酸诱导的 IBD 模型中迅速抑制炎症并修复肠粘膜屏障。这项工作表明，超薄 HfS 2具有增强结肠积累的@TA原子晶体有望用于IBD的靶向治疗。
京公网安备 11010802027423号