Delayed inflammatory reaction and poor osteogenesis are the two main causes of failure for bone-defect healing. Accordingly, in the present study, a dual-responsive hydrogel composite was successfully fabricated in which near-infrared (NIR)-light-responsive polydopamine-coated magnesium‐calcium carbonate microspheres are incorporated into a thermo-responsive hydroxybutyl chitosan hydrogel to provide sequential delivery of the anti-inflammatory drug aspirin and osteogenic bone morphogenetic protein 2 (BMP-2). By initially releasing aspirin rapidly, the hydrogel composite efficiently ameliorates early-stage inflammatory reaction and promotes transition to the regenerative phase. Then, the hydrogel composite allows NIR-light-responsive release of BMP-2, which maximizes its osteoinductive effects. Using an SD rat calvaria-defect model, the sequential and controllable release achieved by the hydrogel is demonstrated to promote new-bone formation. Thus, the current study provides an efficient alternative strategy for developing multifunctional therapeutic biomaterials for bone tissue engineering.

炎症反应迟发和成骨不良是骨缺损愈合失败的两个主要原因。因此，在本研究中，成功​​制造了一种双响应水凝胶复合材料，其中近红外 (NIR)-光响应聚多巴胺涂层的碳酸镁钙微球被掺入到热响应羟丁基壳聚糖水凝胶中，以提供顺序递送。抗炎药阿司匹林和成骨骨形态发生蛋白 2 (BMP-2)。通过最初快速释放阿司匹林，水凝胶复合材料有效地改善了早期炎症反应并促进了向再生阶段的转变。然后，水凝胶复合材料允许 BMP-2 的近红外光响应释放，从而最大限度地发挥其骨诱导作用。使用 SD 大鼠颅骨缺损模型，水凝胶实现的顺序和可控释放被证明可以促进新骨的形成。因此，目前的研究为开发用于骨组织工程的多功能治疗性生物材料提供了一种有效的替代策略。