A KO^tBu-mediated strategy for pyrimidine synthesis via selective three-component coupling reactions has been disclosed. This chemistry, in which a series of pyrimidines (20 examples) can be prepared with moderate to excellent yields, has high potential for large-scale operation owing to its metal-free conditions, atom and step economy. According to mechanistic studies, oxidative species can be generated from KO^tBu or toluene in the presence of air, which can initiate the oxidation of alcohols to aldehydes (or ketones). Meanwhile, KO^tBu not only promotes the condensation-cyclization process, but also triggers the dehydrogenation of dihydropyrimidine ring.

已经公开了一种通过选择性三组分偶联反应合成嘧啶的 KO ^t Bu 介导的策略。这种化学可以以中等至优异的产率制备一系列嘧啶（20 个实例），由于其无金属条件、原子和步骤经济性，具有大规模操作的巨大潜力。根据机理研究，在空气存在下，KO ^t Bu 或甲苯可以生成氧化物质，这可以引发醇氧化成醛（或酮）。同时，KO ^t Bu 不仅促进了缩合环化过程，还引发了二氢嘧啶环的脱氢。