Histidine, a versatile proteinogenic amino acid, plays a broad range of roles in all living organisms and behaves as a key mediator of the interactions of biomolecules with inorganic constituents. The self-assembly of histidine-rich peptides and proteins is critical in biology, as the histidine unit is both a multifunctional regulator and an ideal motif for the construction of complex biological structures. In particular, non-covalent interactions between the imidazole ring and other molecular building blocks and metal ions are routinely employed to generate these complexes. Therefore, this strategy can be duplicated in an artificial context to create sophisticated bioactive materials. In this review, we first highlight a clear perspective of the bio-inspired design strategies which can replicate the hierarchical structure of biological systems allowing the engineering of the supramolecular self-assembly of histidine-functionalized peptides. We further summarize advancements in the field of peptide supramolecular structures incorporating histidine residues in the peptide backbone to generate organized functional supramolecular biomaterials with customizable features. We also discuss significant advances and future prospects in supramolecular self-assembly of histidine-functionalized peptides, as well as provide an overview of advanced techniques for the fabrication of histidine-based biomaterials for bio-nanotechnology, optoelectronic engineering, and biomedicine. Overall, artificial supramolecular materials based on histidine functionalized peptides, motivated by the intriguing properties discovered in natural proteins, bear the potential to boost the creation of sustainable bio-inspired materials.

组氨酸是一种多功能的蛋白质氨基酸，在所有生物体中发挥着广泛的作用，并且是生物分子与无机成分相互作用的关键介质。富含组氨酸的肽和蛋白质的自组装在生物学中至关重要，因为组氨酸单元既是多功能调节剂，也是构建复杂生物结构的理想基序。特别是，咪唑环与其他分子结构单元和金属离子之间的非共价相互作用通常用于生成这些复合物。因此，可以在人工环境中复制该策略以创建复杂的生物活性材料。在这篇评论中，我们首先强调了生物启发设计策略的清晰视角，它可以复制生物系统的层次结构，从而允许组氨酸功能化肽的超分子自组装工程。我们进一步总结了在肽主链中结合组氨酸残基的肽超分子结构领域的进展，以生成具有可定制特征的有组织的功能性超分子生物材料。我们还讨论了组氨酸功能化肽的超分子自组装的重大进展和未来前景，并概述了用于生物纳米技术、光电工程和生物医学的组氨酸生物材料制造的先进技术。全面的，