The quality control of the bacterial cellulose (BC) production has been facing challenges due to the genetic stability of bacterial strains, which is often overlooked or underestimated. Thus, its commercialized application is limited. Therefore, a bacterial strain FM883 with a 16S rRNA sequence 97% identical to Komagataeibacter xylinus NBRC15237^T was isolated from kombucha tea. Cultivation of FM883 was conducted in series to observe the morphology and BC yield among different generations from 1st generation to 30th generation. The results show that FM883 can efficiently produce BC in modified Hestrin-Schramn media at the 30th generation (163.5 ± 0.3 g/L), which was even higher than the 1st generation (157.6 ± 0.3 g/L). This indicated that FM883 has strong genetic stability. Furthermore, several characterizations of the BC indicated that the quality of the BC biosynthesized by FM883 was good with excellent thermostability. With such strong genetic stability, and properties, as well as sufficiently high consistency and high yield, BC biosynthesized by FM883 had demonstrated excellent production quality control, which is desired for commercial manufacturing.

由于细菌菌株的遗传稳定性，细菌纤维素（BC）生产的质量控制一直面临挑战，这一点经常被忽视或低估。因此，其商业化应用受到限制。因此，具有 16 S rRNA序列的菌株 FM883 与Komagataeibacter xylinus NBRC15237 ^T 97% 相同是从康普茶中分离出来的。对FM883进行系列培养，观察第1代至第30代不同代间的形态和BC产量。结果表明，FM883 在第 30 代（163.5 ± 0.3 g/L）的改良 Hestrin-Schramn 培养基中可以高效生产 BC，甚至高于第 1 代（157.6 ± 0.3 g/L）。这表明FM883具有很强的遗传稳定性。此外，BC的几个表征表明FM883生物合成的BC质量良好，具有优异的热稳定性。凭借如此强的遗传稳定性和特性，以及足够高的一致性和高产量，FM883 生物合成的 BC 表现出出色的生产质量控制，这是商业化生产所需要的。