HOCl-Activated Reactive Organic Selenium Delivery Platform for Alleviation of Inflammation,Bioconjugate Chemistry

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HOCl-Activated Reactive Organic Selenium Delivery Platform for Alleviation of Inflammation
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2022-08-26 , DOI: 10.1021/acs.bioconjchem.2c00349
Hongying Peng ₁ , Shi Shi ₂ , Zhenni Lu ₁ , Lingyan Liu ₁ , Shuxin Peng ₁ , Peng Wei ₁ , Tao Yi ₁

Affiliation

Selenium plays an important role in the biological system and can be used to treat various types of diseases. However, the current selenium delivery systems face the problems of low activity of released Se-containing compounds or nonspecific toxicity of reactive organic selenium donors in living systems. In response to these problems, we constructed a reactive organic selenium delivery platform by the activation of HOCl. Compared with prodrugs without activation capability, the hypochloroselenoite derivatives released from the present platform after activation displayed higher reactivity and could react with various nucleophiles to participate in specific life processes. Taking the selected compound (DHU-Se1) as an example, we found that it could alleviate the process of inflammation by blocking the polarization of macrophages from M0 to M1. Therefore, the development of this system is of great significance for expanding the application of selenium-containing compounds and treating related diseases.

中文翻译：

用于减轻炎症的 HOCl 激活反应性有机硒递送平台

硒在生物系统中起着重要作用，可用于治疗多种疾病。然而，目前的硒输送系统面临着释放的含硒化合物活性低或活体系统中反应性有机硒供体的非特异性毒性等问题。针对这些问题，我们通过 HOCl 的活化构建了反应性有机硒递送平台。与没有活化能力的前药相比，本平台活化后释放的次氯硒酸盐衍生物表现出更高的反应活性，可以与多种亲核试剂反应参与特定的生命过程。以选定的化合物 ( DHU-Se1) 例如，我们发现它可以通过阻断巨噬细胞从 M0 到 M1 的极化来缓解炎症过程。因此，该体系的开发对于扩大含硒化合物的应用和治疗相关疾病具有重要意义。

更新日期：2022-08-26

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