Escherichia coli biofilm is a complex membrane aggregation produced by the adhesion and secretion of extracellular polymeric substances by E. coli cells aggregated on specific media. Pathogenic E. coli will evade the immune system and the impact of various harmful factors in the environment after the formation of biofilm, causing sustained and even fatal damage to the host. Cyclic diguanosine monophosphate (c-di-GMP) is a second messenger ubiquitous in bacteria and plays a crucial role in regulating biofilm formation. This paper reviewed the recent studies about the role of c-di-GMP in the movement, adhesion, and EPS production mechanism of E. coli during biofilm formation, aiming to provide a basis for inhibiting E. coli biofilm from the perspective of c-di-GMP.

中文翻译：

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[c-di-GMP在大肠杆菌生物膜调控中的研究进展].

大肠杆菌生物膜是一种复杂的膜聚集体，由聚集在特定培养基上的大肠杆菌细胞粘附和分泌胞外聚合物而产生。致病性大肠杆菌在形成生物膜后会逃避免疫系统和环境中各种有害因素的影响，对宿主造成持续甚至致命的伤害。环状二鸟苷一磷酸 (c-di-GMP) 是细菌中普遍存在的第二信使，在调节生物膜形成中起着至关重要的作用。本文综述了近期关于c-di-GMP在大肠杆菌生物膜形成过程中的运动、粘附和EPS产生机制的研究，旨在从c-di-GMP的角度为抑制大肠杆菌生物膜提供依据。二GMP。