Molecularly Engineered Protein Glues with Superior Adhesion Performance,Advanced Materials

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Molecularly Engineered Protein Glues with Superior Adhesion Performance
Advanced Materials ( IF 27.4 ) Pub Date : 2022-08-25 , DOI: 10.1002/adma.202204590
Zili Wang _{1,

2} , Xinquan Gu ₁ , Bo Li ₂ , Jingjing Li ₂ , Fan Wang ₂ , Jing Sun ₃ , Hongjie Zhang _{2,

4} , Kai Liu _{2,

4} , Weisheng Guo ₅

Affiliation

Naturally inspired proteins are investigated for the development of bioglues that combine adhesion performance and biocompatibility for biomedical applications. However, engineering such adhesives by rational design of the proteins at the molecular level is rarely reported. Herein, it is shown that a new generation of protein-based glues is generated by supramolecular assembly through de novo designed structural proteins in which arginine triggers robust liquid–liquid phase separation. The encoded arginine moieties significantly strengthen multiple molecular interactions in the complex, leading to ultrastrong adhesion on various surfaces, outperforming many chemically reacted and biomimetic glues. Such adhesive materials enable quick visceral hemostasis in 10 s and outstanding tissue regeneration due to their robust adhesion, good biocompatibility, and superior antibacterial capacity. Remarkably, their minimum inhibitory concentrations are orders of magnitude lower than clinical antibiotics. These advances offer insights into molecular engineering of de novo designed protein glues and outline a general strategy to fabricate mechanically strong protein-based materials for surgical applications.

中文翻译：

具有卓越粘附性能的分子工程蛋白胶

研究了受自然启发的蛋白质，以开发结合了生物医学应用的粘附性能和生物相容性的生物胶。然而，很少报道通过在分子水平上合理设计蛋白质来设计这种粘合剂。在此，显示了新一代蛋白质基胶是通过从头设计的结构蛋白进行超分子组装产生的，其中精氨酸触发强大的液-液相分离。编码的精氨酸部分显着增强了复合物中的多种分子相互作用，导致在各种表面上的超强粘附力，优于许多化学反应和仿生胶水。这种粘合剂材料由于其强大的粘附性、良好的生物相容性、和超强的抗菌能力。值得注意的是，它们的最低抑菌浓度比临床抗生素低几个数量级。这些进展为从头设计的蛋白质胶的分子工程提供了见解，并概述了制造用于外科应用的机械强度高的蛋白质基材料的一般策略。

更新日期：2022-08-25

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