Novel insights into the regulation of cellular catabolic metabolism in macrophages through nuclear receptors,FEBS Letters

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Novel insights into the regulation of cellular catabolic metabolism in macrophages through nuclear receptors
FEBS Letters ( IF 3.0 ) Pub Date : 2022-08-23 , DOI: 10.1002/1873-3468.14474
Ulrich Stifel ₁ , Giorgio Caratti _{1,

2,

3} , Jan Tuckermann ₁

Affiliation

Regulation of cellular catabolic metabolism in immune cells has recently become a major concept for resolution of inflammation. Nuclear receptors (NRs), including peroxisome proliferator activator receptors, 1,25-dihydroxyvitamin D (3) receptor, liver X receptors, glucocorticoid receptors, oestrogen-related receptor α and nuclear receptor 4A1, have been identified as major modulators of inflammation, affecting innate immune cells, such as macrophages. Evidence emerges on how NRs regulate cellular metabolism in macrophages during inflammatory processes and contribute to the resolution of inflammation. This could have new implications for our understanding of how NRs shape immune responses and inform anti-inflammatory drug design. This review will highlight the recent developments about NRs and their role in cellular metabolism in macrophages.

中文翻译：

通过核受体调节巨噬细胞细胞分解代谢的新见解

免疫细胞中细胞分解代谢的调节最近已成为解决炎症的主要概念。核受体 (NR)，包括过氧化物酶体增殖物激活剂受体、1,25-二羟基维生素 D (3) 受体、肝 X 受体、糖皮质激素受体、雌激素相关受体 α 和核受体 4A1，已被确定为炎症的主要调节剂，影响先天免疫细胞，例如巨噬细胞。关于 NRs 如何在炎症过程中调节巨噬细胞中的细胞代谢并促进炎症消退的证据不断涌现。这可能对我们理解 NRs 如何塑造免疫反应和指导抗炎药物设计产生新的影响。本综述将重点介绍 NR 的最新进展及其在巨噬细胞细胞代谢中的作用。

更新日期：2022-08-23

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