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Switching to a ‘turn-on’ fluorescent probe for rapid detection of hydrazine in human breast cancer cells using a test-strip
Analytical Methods ( IF 2.7 ) Pub Date : 2022-08-23 , DOI: 10.1039/d2ay01157c
Anirban Karak 1 , Moumi Mandal 1 , Satyajit Halder 2 , Shilpita Banerjee 1 , Dipanjan Banik 1 , Anwesha Maiti 1 , Kuladip Jana 2 , Ajit Kumar Mahapatra 1
Analytical Methods ( IF 2.7 ) Pub Date : 2022-08-23 , DOI: 10.1039/d2ay01157c
Anirban Karak 1 , Moumi Mandal 1 , Satyajit Halder 2 , Shilpita Banerjee 1 , Dipanjan Banik 1 , Anwesha Maiti 1 , Kuladip Jana 2 , Ajit Kumar Mahapatra 1
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A fluorescent probe TPSBT was developed to monitor hydrazine detection with a “turn on” response, converting from a “non-responsive” probe by a simple structural modification. The probe shows very weak fluorescence due to the strong ICT process and upon treatment with hydrazine, green fluorescence appears due to the blocking of this ICT by the formation of a hydrazone. The probe TPSBT can detect hydrazine with a very low detection limit (1.22 × 10−7 M) and within a very short time period of 50 s. Additionally, the probe is able to give a response in live cell imaging (MDA-MB 231) and also in the solid phase.
中文翻译：
切换到“开启”荧光探针，使用试纸快速检测人乳腺癌细胞中的肼
开发了一种荧光探针TPSBT来监测具有“开启”响应的肼检测，通过简单的结构修饰从“非响应”探针转变。由于强烈的 ICT 过程，探针显示出非常微弱的荧光，并且在用肼处理后，由于形成腙而阻断了该 ICT，因此出现绿色荧光。探针TPSBT可以以非常低的检测限（1.22×10 -7 M）在50秒的非常短的时间内检测肼。此外，该探针能够在活细胞成像 (MDA-MB 231) 和固相中给出响应。
更新日期：2022-08-23
中文翻译：
切换到“开启”荧光探针，使用试纸快速检测人乳腺癌细胞中的肼
开发了一种荧光探针TPSBT来监测具有“开启”响应的肼检测，通过简单的结构修饰从“非响应”探针转变。由于强烈的 ICT 过程，探针显示出非常微弱的荧光，并且在用肼处理后，由于形成腙而阻断了该 ICT，因此出现绿色荧光。探针TPSBT可以以非常低的检测限（1.22×10 -7 M）在50秒的非常短的时间内检测肼。此外，该探针能够在活细胞成像 (MDA-MB 231) 和固相中给出响应。
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