An Injectable Rapid-Adhesion and Anti-Swelling Adhesive Hydrogel for Hemostasis and Wound Sealing,Advanced Functional Materials

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An Injectable Rapid-Adhesion and Anti-Swelling Adhesive Hydrogel for Hemostasis and Wound Sealing
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2022-08-19 , DOI: 10.1002/adfm.202207741
Shaoquan Bian ₁ , Liuzhi Hao _{1,

2} , Xin Qiu ₁ , Jun Wu ₃ , Hao Chang ₁ , Guan‐Ming Kuang ₃ , Sheng Zhang ₄ , Xiaohua Hu ₅ , Yakang Dai ₆ , Zhiyong Zhou ₆ , Fangli Huang ₇ , Chun Liu ₇ , Xuenong Zou ₇ , Wenguang Liu ₈ , Willima W. Lu _{1,

9} , Haobo Pan ₁ , Xiaoli Zhao _{1,

2}

Affiliation

Research Center for Human Tissue and Organs Degeneration Institute of Biomedicine and Biotechnology Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China
Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma Department of Orthopaedics and Traumatology The University of Hong Kong‐Shenzhen Hospital Shenzhen 518048 China
University of Chinese Academy of Sciences Beijing 100049 China
Department of orthopedics Nanfang Hospital Affiliate to Southern Medical University Guangzhou 510515 China
Department of Burns and Plastic Surgery Beijing Jishuitan Hospital Beijing 100035 China
Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou 215163 China
Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology Department of Spine Surgery Institute of Orthopaedic Research The First Affiliated Hospital of Sun Yat‐sen University Guangzhou 510080 China
School of Material Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300072 China
Department of Orthopaedics and Traumatology Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong 999077 China

Injectable hydrogel adhesives integrating both rapid adhesion to wet tissues and anti-swelling in humid environments are highly desired for fast hemostasis and wound sealing in surgical applications. Herein, utilizing the synergistic effect of thermo-sensitive shrinkable nano-micelle gelators and small molecular adhesive moieties, an injectable hydrogel with rapid-adhesion and anti-swelling properties (RAAS hydrogel) is fabricated. The RAAS hydrogel can undergo ultrafast gelation to achieve wet adhesion within 2 s of ultraviolet illumination and exhibit an outstanding anti-swelling performance with non-expansion of volume during the whole degradation process. It also presents good biocompatibility and low risk of hemolysis. Its fast hemostasis is demonstrated in diverse hemorrhage models with injuries in the liver, artery, heart, cranial vessel, and brain cortex in small animals. Importantly, its volume stability in humid internal environment can maintain the strong adhesion strength and avoid compression injury to spinal cord when applied for dura sealing. These data suggest that the injectable RAAS hydrogel holds potential for the applications of fast hemostasis and wound sealing with the benefits of stable adhesion and reducing the risk of tissue compression injury.

中文翻译：

一种用于止血和伤口密封的可注射快速粘合和抗肿胀粘合水凝胶

可注射的水凝胶粘合剂结合了对湿组织的快速粘附和在潮湿环境中的抗肿胀，非常需要用于外科应用中的快速止血和伤口密封。在此，利用热敏可收缩纳米胶束凝胶剂和小分子粘合剂部分的协同作用，制备了一种具有快速粘附和抗膨胀性能的可注射水凝胶（RAAS 水凝胶）。RAAS水凝胶在紫外线照射下2秒内即可实现超快凝胶化，实现湿粘合，并在整个降解过程中表现出优异的抗溶胀性能且体积不膨胀。它还具有良好的生物相容性和低溶血风险。其快速止血在肝脏、动脉、心脏、颅血管损伤的多种出血模型中得到证实，和小动物的大脑皮层。重要的是，其在潮湿的内部环境中的体积稳定性可以保持强大的粘附强度，并在用于硬脑膜密封时避免对脊髓的压缩损伤。这些数据表明，可注射的 RAAS 水凝胶具有快速止血和伤口密封应用的潜力，具有稳定粘附和降低组织压缩损伤风险的好处。

更新日期：2022-08-19

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