The aim of the current study was to prepare glutamic acid/polyvinyl alcohol based hydrogels by the free radical polymerization technique. The FTIR analysis of glutamic acid, polyvinyl alcohol, acrylic acid, and ketorolac tromethamine indicated the development and loading of the drug by the prepared hydrogels. DSC and TGA revealed the increase in the thermal stability of glutamic acid and polyvinyl alcohol after crosslinking and polymerization process, thus revealed high thermal stability for the fabricated hydrogel as compared to hydrogel contents. XRD depicted a reduction in the crystallinity of the reagents, which indicated the strong crosslinking and formation of a new polymeric network of hydrogel. SEM indicated a hard and dense surface of the prepared hydrogel, which may be correlated with the strong polymerization among hydrogel contents. Similarly, the effects of cross-linked polymers and monomer on polymer volume fraction, dynamic swelling and in-vitro drug release studies were investigated in three different pH values i.e., pH 1.2, 4.6, and 7.4, respectively. High swelling and drug release were observed as the pH of the medium was enhanced from 1.2 to 4.6 and 7.4, thus, revealed a pH-responsive nature of the prepared hydrogels. Moreover, percent porosity and drug loading were performed for fabricated hydrogels. Increase in percent porosity and drug loading was seen with the increasing composition of glutamic acid and acrylic acid while a decrease was perceived with the increase in the composition of polyvinyl alcohol. Results of sol-gel analysis revealed an increase in the cross-linking degree of the hydrogels with the increasing composition of glutamic acid, polyvinyl alcohol, and acrylic acid, while a decrease in un-crosslinking was observed, respectively. The degradation rate of hydrogel was decreased as the compositions of glutamic acid, polyvinyl alcohol, and acrylic acid was increased, which indicated a compatible network formation of hydrogel with the incorporation of high hydrogel contents. Similarly, in-vivo study was performed on rabbits and the results of pharmacokinetic parameters indicated a controlled release of the drug from the developed hydrogels for a long period of time. HET-CAM test revealed no toxic effect of the polymeric hydrogel on the chorioallantoic membrane of the fertilized chicken eggs. Therefore, regarding the results of all studies, we can conclude that the prepared hydrogels could be used for the controlled drug delivery system.

本研究的目的是通过自由基聚合技术制备谷氨酸/聚乙烯醇基水凝胶。谷氨酸、聚乙烯醇、丙烯酸和酮咯酸氨丁三醇的 FTIR 分析表明制备的水凝胶对药物的开发和负载。DSC 和 TGA 显示谷氨酸和聚乙烯醇在交联和聚合过程后的热稳定性增加，因此与水凝胶含量相比，制备的水凝胶具有较高的热稳定性。XRD 描绘了试剂结晶度的降低，这表明强烈的交联并形成了新的水凝胶聚合物网络。SEM表明制备的水凝胶表面坚硬致密，这可能与水凝胶内容物之间的强聚合有关。体外在三种不同的 pH 值下研究药物释放研究，即分别为 pH 1.2、4.6 和 7.4。随着介质的 pH 从 1.2 提高到 4.6 和 7.4，观察到高溶胀和药物释放，因此揭示了制备的水凝胶的 pH 响应性质。此外，对制造的水凝胶进行了孔隙率百分比和载药量。随着谷氨酸和丙烯酸组成的增加，孔隙率百分比和载药量增加，而随着聚乙烯醇组成的增加，孔隙率和载药量下降。溶胶-凝胶分析结果显示，随着谷氨酸、聚乙烯醇和丙烯酸组成的增加，水凝胶的交联度增加，而未交联度分别降低。随着谷氨酸、聚乙烯醇和丙烯酸组成的增加，水凝胶的降解速率降低，这表明水凝胶的相容性网络形成与高水凝胶含量的结合。类似地，对兔子进行了体内研究，药代动力学参数的结果表明药物从开发的水凝胶中长时间受控释放。HET-CAM 测试显示聚合物水凝胶对受精鸡蛋的尿囊膜没有毒性作用。因此，关于所有研究的结果，我们可以得出结论，制备的水凝胶可用于受控药物输送系统。这表明水凝胶的相容网络形成与高水凝胶含量的结合。类似地，对兔子进行了体内研究，药代动力学参数的结果表明药物从开发的水凝胶中长时间受控释放。HET-CAM 测试显示聚合物水凝胶对受精鸡蛋的尿囊膜没有毒性作用。因此，关于所有研究的结果，我们可以得出结论，制备的水凝胶可用于受控药物输送系统。这表明水凝胶的相容网络形成与高水凝胶含量的结合。类似地，对兔子进行了体内研究，药代动力学参数的结果表明药物从开发的水凝胶中长时间受控释放。HET-CAM 测试显示聚合物水凝胶对受精鸡蛋的尿囊膜没有毒性作用。因此，关于所有研究的结果，我们可以得出结论，制备的水凝胶可用于受控药物输送系统。HET-CAM 测试显示聚合物水凝胶对受精鸡蛋的尿囊膜没有毒性作用。因此，关于所有研究的结果，我们可以得出结论，制备的水凝胶可用于受控药物输送系统。HET-CAM 测试显示聚合物水凝胶对受精鸡蛋的尿囊膜没有毒性作用。因此，关于所有研究的结果，我们可以得出结论，制备的水凝胶可用于受控药物输送系统。