酚酸 - 具有多种生物学应用的多功能天然成分,Current Topics in Medicinal Chemistry

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酚酸 - 具有多种生物学应用的多功能天然成分
Current Topics in Medicinal Chemistry ( IF 2.9 ) Pub Date : 2022-06-24 , DOI: 10.2174/1568026622666220623114450
Renu Sehrawat ₁ , Priyanka Rathee ₂ , Esra Küpelli Akkol ₃ , Sarita Khatkar ₄ , Amit Lather ₄ , Neelam Redhu ₅ , Anurag Khatkar ₆

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背景：近年来，天然酚酸及其合成衍生物的药用用途有所增加。酚酸是化学上确定的次生植物代谢产物，作为分子或前导化合物在自然界中用途广泛，具有广泛的生物活性，引起了世界各地研究人员的关注，合成了不同的酚酸衍生物，并筛选了它们的各种生物学特性。这些化合物是由于它们所具有的特性和它们的出现而引起了极大的兴趣。根据文献中报道的令人信服的证据，表明酚酸及其衍生物是有前途的药物分子。目标：本综述旨在汇集有关生物合成、代谢、和酚酸的来源，并强调酚酸及其合成衍生物的治疗潜力，为有兴趣设计药物以进一步研究的研究人员全面描绘当前的情况。结论：作为基团或铅的酚酸在自然界中用途广泛，因为它们具有广泛的生物活性，如抗菌、抗氧化、抗病毒、抗溃疡、抗炎、抗糖尿病、抗癌等，这为研究人员提供了更多关于这些或在医学领域有许多未开发的好处。本文中提到的信息将有助于即将在该领域工作的研究人员。

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Phenolic Acids - Versatile Natural Moiety with Numerous Biological Applications

Background: Medicinal uses of natural phenolic acids and its synthetic derivatives have been augmented in recent years. Phenolic acids are chemically defined secondary plant metabolitesand being moieties or leads are much versatile in nature with a widescope of biological activities which seek the attention of researchers across the worldto synthesize different derivatives of phenolic acids and screen them for their various biological properties.These compounds are of meticulous interest due to the properties they possess and their occurrence.Based on the convincing evidences reported in the literature, it is suggested that phenolic acids andtheir derivatives are promising molecules as a drug. Objective: The present review article aims to bring together the information on the biosynthesis, metabolism, and sources of phenolic acids and emphasize on the therapeutic potential of phenolic acid and its synthetic derivatives to comprehensively portray the current scenery for researchers interested in designing drugs for furthering this study. Conclusion: Phenolic acids being moieties or lead are much versatile in nature as they possess a wide range of biological activities like antimicrobial, antioxidant, antiviral, antiulcer, anti-inflammatory, antidiabetic, anticancer and many more which offers researchers to explore more about these or many untapped benefits in medicinal field. The information mentioned in this article will be helpful to the forthcoming researchers working in this area. Phenolic acids have massive potential to be investigated for novel medicinal possibilities and for the development of new chemical moieties to treat different diseases of clinical importance.

更新日期：2022-06-24

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