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2D Cu-Bipyridine MOF Nanosheet as an Agent for Colon Cancer Therapy: A Three-in-One Approach for Enhancing Chemodynamic Therapy
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-08-17 , DOI: 10.1021/acsami.2c11999 Chengbin Wang 1, 2 , Fengfeng Xue 1 , Mengxin Wang 2 , Lu An 2 , Dan Wu 1 , Qiwei Tian 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-08-17 , DOI: 10.1021/acsami.2c11999 Chengbin Wang 1, 2 , Fengfeng Xue 1 , Mengxin Wang 2 , Lu An 2 , Dan Wu 1 , Qiwei Tian 1
Affiliation
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Chemodynamic therapy (CDT) is a highly tumor-specific and minimally invasive treatment that is widely used in cancer therapy. However, its therapeutic effect is limited by the poor efficiency of hydroxyl radical generation. In colon cancer in particular, the high expression of hydrogen sulfide (H2S), which has strong reducibility, results in the consumption of generated hydroxyl radicals, further weakening the efficacy of CDT. To overcome this problem, we developed a novel two-dimensional (2D) Cu-bipyridine metal–organic framework (MOF) nanosheet [Cu(bpy)2(OTf)2] for colon cancer CDT. The therapeutic effect of Cu(bpy)2(OTf)2 is enhanced based on three factors. First, the developed 2D Cu-MOF rapidly consumes H2S to inhibit the consumption of generated hydroxyl radicals. Second, the ultrasmall CuS generated after H2S depletion facilitates Fenton-like reactions. Third, the generated CuS exhibits good photothermal performance in the second near-infrared window, allowing for photothermal-enhanced CDT. The ability of Cu(bpy)2(OTf)2 to improve the CDT effect was demonstrated through both in vitro and in vivo experiments. This work demonstrates the applicability of 2D Cu-MOF in the CDT of colon cancer and provides a novel strategy for constructing CDT agents for colon cancer.
中文翻译：
2D Cu-联吡啶 MOF 纳米片作为结肠癌治疗剂：增强化学动力学治疗的三合一方法
化学动力学疗法（CDT）是一种高度肿瘤特异性和微创治疗，广泛用于癌症治疗。然而，其治疗效果受到羟基自由基产生效率低下的限制。特别是在结肠癌中，还原性强的硫化氢（H 2 S）的高表达导致生成的羟基自由基被消耗，进一步削弱了CDT的功效。为了克服这个问题，我们开发了一种用于结肠癌 CDT的新型二维 (2D) Cu-联吡啶金属-有机框架 (MOF) 纳米片 [Cu(bpy) 2 (OTf) 2 ]。Cu(bpy) 2 (OTf) 2的治疗作用增强基于三个因素。首先，开发的 2D Cu-MOF 快速消耗 H 2 S 以抑制生成的羟基自由基的消耗。其次，H 2 S 耗尽后产生的超小 CuS促进了类芬顿反应。第三，生成的 CuS 在第二近红外窗口中表现出良好的光热性能，可用于光热增强 CDT。通过体外和体内实验证明了 Cu(bpy) 2 (OTf) 2改善 CDT 效应的能力。这项工作证明了二维 Cu-MOF 在结肠癌 CDT 中的适用性，并为构建结肠癌 CDT 试剂提供了一种新策略。
更新日期：2022-08-17
中文翻译：
2D Cu-联吡啶 MOF 纳米片作为结肠癌治疗剂：增强化学动力学治疗的三合一方法
化学动力学疗法（CDT）是一种高度肿瘤特异性和微创治疗，广泛用于癌症治疗。然而，其治疗效果受到羟基自由基产生效率低下的限制。特别是在结肠癌中，还原性强的硫化氢（H 2 S）的高表达导致生成的羟基自由基被消耗，进一步削弱了CDT的功效。为了克服这个问题，我们开发了一种用于结肠癌 CDT的新型二维 (2D) Cu-联吡啶金属-有机框架 (MOF) 纳米片 [Cu(bpy) 2 (OTf) 2 ]。Cu(bpy) 2 (OTf) 2的治疗作用增强基于三个因素。首先，开发的 2D Cu-MOF 快速消耗 H 2 S 以抑制生成的羟基自由基的消耗。其次，H 2 S 耗尽后产生的超小 CuS促进了类芬顿反应。第三，生成的 CuS 在第二近红外窗口中表现出良好的光热性能，可用于光热增强 CDT。通过体外和体内实验证明了 Cu(bpy) 2 (OTf) 2改善 CDT 效应的能力。这项工作证明了二维 Cu-MOF 在结肠癌 CDT 中的适用性，并为构建结肠癌 CDT 试剂提供了一种新策略。
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