Antibiotics residues are still an important and noticeable issue, and realizing the ultra-sensitive, sample, and rapid detection of residual antibiotics in the environment is the basis for evaluating and monitoring the pollution status. Herein, a new bimetallic PtNi nanozyme-driven dual-amplified photoelectrochemical (PEC) aptasensor was developed for sulfamethazine (SMZ) assay based on the superior photosensitive material of Z-scheme heterostructured Co₉S₈@ In doped CdS nanotubes (Co₉S₈@In-CdS NTs). In this protocol, bimetallic alloyed nanotube PtNi was introduced as the mimic enzyme to instead of bio-enzyme for constructing of signal amplification strategy. On the basis of the outstanding photosensitivity of Co₉S₈@In-CdS NTs and highly catalytic property of PtNi nanozyme, the proposed PEC aptasensor exhibits a wide linear range of 0.05 pg mL^–1 ~ 1.0 ng mL^–1, and a low detection limit of 37.2 fg mL^–1. This work put forwards a novel approach for the accurate analysis of antibiotics in the environment.

抗生素残留仍然是一个重要且值得关注的问题，实现环境中残留抗生素的超灵敏、样品、快速检测是评价和监测污染状况的基础。在此，基于 Z 型异质结构 Co ₉ S ₈ @ In 掺杂的 CdS 纳米管 (Co ₉ S ₈ @In-CdS NTs）。在该协议中，引入了双金属合金纳米管 PtNi 作为模拟酶，而不是生物酶，用于构建信号放大策略。基于 Co _{9出色的感光性}S ₈ @In-CdS NTs 和 PtNi 纳米酶的高催化性能，所提出的 PEC 适体传感器具有 0.05 pg mL ^-1 ~ 1.0 ng mL ^{-1的宽线性范围和 37.2 fg mL -1}的低检测限。这项工作为准确分析环境中的抗生素提出了一种新方法。